Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSL1 (P33121) - Overview - Molecular Target Synopsis

Protein


ACSL1, Long-chain-fatty-acid--CoA ligase 1
Enzyme Classification 6.2.1.3
UniProt P33121

Also Known as ACSL1_HUMAN, ACSL1, FACL1, FACL2, LACS, LACS1, LACS2

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSL1 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane, mitochondrion outer membrane, peroxisome membrane.
GO terms: ACSL1 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSL1 has gain in 0 cell-lines, loss in 12 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, M14, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 888, NCI-H1781, HCC2688

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, HSMM

(see details)


Screening and Chemistry


ACSL1 has been screened with compounds ( bioactivities). (see details)