Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

GSP1 (P32835) - Overview - Molecular Target Synopsis


GSP1, GTP-binding nuclear protein GSP1/CNR1
UniProt P32835

Also Known as GSP1_YEAST, GSP1, CNR1, CST17

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1. Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Forms a complex with YRB1. Interacts with BUD5, CEX1, RRP12, SRM1, and DIS3/RRP44.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: GSP1 is active in the following subcellular-locations: nucleus.
GO terms: GSP1 is active in the following subcellular-locations: cytoplasm, cytosol, integral component of membrane, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project GSP1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For GSP1 there are:
4 structures (5 chains) solved
4 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

GSP1 has been screened with compounds ( bioactivities). (see details)