Molecular Target Synopsis
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RRN6 (P32786) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed15
Chains with at least one site assessed as druggable using the strict criteria9
Chains with at least one site assessed as druggable using the relaxed criteria15


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5O7X_P RNA polymerase I-specific transcription initiation factor RRN6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 63.4 45.5 Yes No
2 empty 2 78.5 35.6 No No
3 empty 2.22 62 25.6 No No
4 empty 2.06 68 27.6 No No
5 empty 2.35 60.2 23.5 No No
6 empty 2.4 67.5 20.7 No No
7 empty 2.36 73.5 18.4 No No
8 bound 1.92 64.8 23.7 No No
9 empty 2.21 71 16.3 No No
10 empty 2.11 67.8 16.8 No No
5W65_O RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 66.7 54.5 Yes Yes
2 empty 2.21 84.4 37.4 Yes Yes
3 empty 2.33 68.9 34.4 No No
4 empty 2.4 72.5 32.3 No No
5 empty 2.31 69.5 34.1 No No
6 empty 2.15 72.7 39.8 No No
7 empty 2.17 62.5 29.4 No No
8 empty 2 60.1 24 No No
9 empty 2.14 70 21.3 No No
10 empty 2.37 71.4 21.8 No No
5O7X_J RNA polymerase I-specific transcription initiation factor RRN6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 62.9 38.4 Yes No
2 empty 1.99 78.7 34.2 No No
3 empty 2.04 62.7 26.3 No No
4 empty 2.13 67.8 25.4 No No
5 empty 2.38 59.1 24.3 No No
6 empty 2.41 67.8 20.7 No No
7 empty 2.3 71.9 18.6 No No
8 empty 1.91 65.3 19.6 No No
9 empty 2.06 70.5 19 No No
10 empty 2.26 69.9 16.9 No No
5N60_P RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 73.8 53.4 Yes Yes
2 empty 2.2 67.7 41.6 No No
3 empty 2.33 67.9 35.3 No No
4 empty 1.58 64.9 29.3 No No
5 empty 1.86 65.1 35.4 No No
6 empty 2.14 75.3 26 No No
7 empty 2.1 70.1 21.7 No No
8 empty 1.86 60.5 22.3 No No
9 empty 2.09 77.1 14.4 No No
10 empty 2.22 72.2 17.1 No No
5N5Y_P RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 72.3 58.6 Yes Yes
2 empty 2.25 67.7 40.5 No No
3 empty 1.9 55.3 23.7 No No
4 empty 2.39 75.9 31.3 No No
5 bound 2.02 65.8 26 No No
6 empty 2.19 76 20.7 No No
7 empty 2.11 69.9 19.9 No No
8 empty 1.83 61.5 23.9 No No
9 empty 2.13 75.8 17.8 No No
10 empty 2.17 72.3 17.1 No No
5W5Y_O RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 66.8 45.8 Yes Yes
2 empty 2.21 84.7 36.6 Yes Yes
3 empty 2.41 67.6 47.1 No No
4 empty 2.3 71 34.4 No No
5 empty 2.17 72.5 32.6 No No
6 empty 2.06 64.2 34.3 No No
7 empty 2.27 65.3 41 No No
8 empty 2.43 73.3 28.3 No No
9 empty 2.22 71.4 27.2 No No
10 empty 2.09 72 23.6 No No
5N5Z_P RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 72.6 59.8 Yes Yes
2 empty 2.54 68.8 47 No No
3 empty 1.9 66.3 22.2 No No
4 empty 2.11 74.6 21.7 No No
5 empty 2.06 66.2 29.7 No No
6 empty 1.87 60.7 23.6 No No
7 empty 2.04 76.4 15.7 No No
8 empty 2.2 74.3 17.8 No No
9 empty 2.3 69.7 17.2 No No
10 empty 2.21 60.8 16 No No
5N61_P RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 71.5 62.6 Yes Yes
2 empty 2.13 67 46.8 No No
3 empty 2.04 64.1 38 No No
4 empty 2.36 75.1 31.2 No No
5 empty 1.93 68.1 17 No No
6 empty 2.07 66.6 21.2 No No
7 empty 2.1 77.9 15.2 No No
8 empty 2.16 75.2 17.9 No No
9 empty 2.17 70.6 17.8 No No
10 empty 1.64 58.3 17 No No
5W64_O RNA polymerase I-specific transcription initiation factor RRN6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 66 44.2 Yes No
2 empty 2.43 67.4 53.2 No No
3 empty 2.26 84.3 36.9 Yes No
4 empty 2.25 68.3 37.6 No No
5 empty 2.16 73.2 30.4 No No
6 empty 2.21 72.5 33.7 No No
7 empty 1.99 62.9 34.4 No No
8 empty 2.05 72.7 27.5 No No
9 empty 1.9 60.9 20.8 No No
10 empty 2.3 72.4 23.3 No No
5OA1_V RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 75.3 48.5 Yes Yes
2 empty 1.86 73.7 29.9 No No
3 empty 2.24 77.6 27.9 No No
4 empty 2.15 82 28 No No
5 empty 2.79 58.4 7 No No
6 empty 2.26 72.2 4.8 No No
7 empty 2.16 62.3 4 No No
5W66_O RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 65.1 42.4 Yes No
2 empty 2.33 78.8 38.3 Yes Yes
3 empty 2.44 69.2 53.7 No No
4 empty 2.29 65.6 41.1 No No
5 empty 2.32 70.1 36.6 No No
6 empty 2.22 74 33.2 No No
7 empty 2.11 61.3 20.5 No No
8 empty 2.03 74 22.2 No No
9 empty 2.4 68.7 30.9 No No
10 empty 2.34 76.8 20.7 No No
5O7X_D RNA polymerase I-specific transcription initiation factor RRN6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 63 45.5 Yes No
2 empty 2.03 75.3 44.4 No No
3 empty 2.2 68.4 30.3 No No
4 empty 2.01 63.3 26.2 No No
5 empty 2.39 60.2 24.5 No No
6 empty 2.42 67.5 23.9 No No
7 empty 2.2 74.4 20.8 No No
8 bound 1.92 61.7 24.2 No No
9 empty 2.17 68.6 17.3 No No
10 empty 2.07 70.4 12.9 No No
5O7X_M RNA polymerase I-specific transcription initiation factor RRN6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 64.1 38.6 Yes No
2 empty 1.98 74.3 35 No No
3 empty 2.19 68.6 32.1 No No
4 empty 2.17 63.1 25.5 No No
5 empty 2.38 66.7 22.8 No No
6 empty 2.21 53.6 18.8 No No
7 bound 1.92 64.8 21 No No
8 empty 2.27 70.7 18.1 No No
9 empty 2.25 69.6 14.6 No No
10 empty 2.07 67.8 18.1 No No
5O7X_G RNA polymerase I-specific transcription initiation factor RRN6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 76 52.3 Yes Yes
2 empty 2.31 67.7 40.8 No No
3 empty 2.11 70 38.5 No No
4 empty 2.04 64.8 25.8 No No
5 empty 2.54 66.3 26.2 No No
6 bound 1.92 67.3 29.1 No No
7 empty 2.24 77.8 19.7 No No
8 empty 2.08 65.4 22.1 No No
9 empty 1.88 63.1 22.6 No No
10 empty 2.35 68.8 23.3 No No
5O7X_A RNA polymerase I-specific transcription initiation factor RRN6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 64.3 40.6 Yes No
2 empty 2 75.1 45.8 No No
3 empty 2.13 68.5 31 No No
4 empty 1.87 63.4 26.5 No No
5 empty 2.4 59.5 24.2 No No
6 empty 2.38 66.3 21.9 No No
7 bound 1.97 62.7 23.3 No No
8 empty 2.08 68.5 15.9 No No
9 empty 2.23 65.5 15.7 No No
10 empty 2.23 62.6 15.3 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score