Molecular Target Synopsis
Overview
Domains and Structures
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Chemistry
Ligand Efficiency Plot
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RRN6 (P32786) - Overview - Molecular Target Synopsis

Protein


RRN6, RNA polymerase I-specific transcription initiation factor RRN6
UniProt P32786

Also Known as RRN6_YEAST, RRN6

Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex. Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN6 interacts with RRN7, RRN11 and RRN9.

5O7X
CRYSTAL STRUCTURE OF S. CEREVISIAE CORE FACTOR AT 3.2A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for RRN6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
894P32786-1

Sub-cellular localization


UniProt: RRN6 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleus.
GO terms: RRN6 is active in the following subcellular-locations: cytoplasm, RNA polymerase I core factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RRN6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RRN6 there are:
10 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis