Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TOA2 (P32774) - Overview - Molecular Target Synopsis

Protein


TOA2, Transcription initiation factor IIA subunit 2
UniProt P32774

Also Known as T2AG_YEAST, TOA2

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. TFIIA is a heterodimer composed of the large TOA1 and a small TOA2 subunits. Interacts with TBP. Interacts with TAF11. Interacts with KAP122.

6GYK
STRUCTURE OF A YEAST CLOSED COMPLEX (CORE CC1)
RCSB/PDB
Inspect Structure
See all 3D Structures for TOA2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
122P32774-1

Sub-cellular localization


UniProt: TOA2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TOA2 is active in the following subcellular-locations: cytoplasm, transcription factor TFIIA complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TOA2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For TOA2 there are:
12 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TOA2 has been screened with compounds ( bioactivities). (see details)