Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TOA1 (P32773) - Overview - Molecular Target Synopsis

Protein


TOA1, Transcription initiation factor IIA large subunit
UniProt P32773

Also Known as TOA1_YEAST, TOA1

TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein). TFIIA is a heterodimer composed of the large TOA1 and a small TOA2 subunits. Interacts with KAP122.

6GYL
STRUCTURE OF A YEAST CLOSED COMPLEX WITH DISTORTED DNA (CORE CCDIST)
RCSB/PDB
Inspect Structure
See all 3D Structures for TOA1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
286P32773-1

Sub-cellular localization


UniProt: TOA1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TOA1 is active in the following subcellular-locations: cytoplasm, transcription factor TFIIA complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TOA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For TOA1 there are:
12 structures (14 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TOA1 has been screened with compounds ( bioactivities). (see details)