Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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FLO1 (P32768) - Overview - Molecular Target Synopsis

Protein


FLO1, Flocculation protein FLO1
UniProt P32768

Also Known as FLO1_YEAST, FLO1, FLO2, FLO4, FLO8

Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Also involved in cell-substrate adhesion.

4LHN
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE FLO1 ADHESIN (N-FLO1P) FROM THE YEAST SACCHAROMYCES CEREVISIAE, IN COMPLEX WITH CALCIUM AND MANNOSE
RCSB/PDB
Inspect Structure
See all 3D Structures for FLO1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1537P32768-1

Sub-cellular localization


UniProt: FLO1 is active in the following subcellular-locations: cell membrane, cell wall, secreted.
GO terms: FLO1 is active in the following subcellular-locations: anchored component of membrane, cell periphery, extracellular region, fungal-type cell wall, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FLO1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For FLO1 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis