Molecular Target Synopsis
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SRB5 (P32585) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed17
Chains with at least one site assessed as druggable using the strict criteria14
Chains with at least one site assessed as druggable using the relaxed criteria17


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HZM_F Mediator of RNA polymerase II transcription subunit 18 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 65.5 46.8 Yes No
2 empty 2.04 66.5 33.6 No No
3 empty 1.9 62.8 21.7 No No
4 empty 2.12 68.4 12.1 No No
5 empty 2.32 68.6 13.4 No No
6 empty 2.2 66.7 10.5 No No
7 empty 2.52 52.5 15 No No
8 empty 1.91 76.1 12.1 No No
9 empty 1.77 61 10.2 No No
10 empty 1.54 55 11.8 No No
2HZM_H Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 66.8 53 Yes Yes
2 empty 1.93 61.3 23.8 No No
3 empty 2.21 63.8 14.1 No No
4 empty 2.25 59.1 16.7 No No
5 empty 2.06 54.9 13.3 No No
6 empty 2.17 69.4 13.7 No No
7 empty 2.02 67.5 10.7 No No
8 empty 2.36 63.1 11.4 No No
9 empty 2.11 79.5 9.3 No No
10 empty 2.29 63 8.9 No No
2HZM_D Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 68.7 48.7 Yes Yes
2 empty 2.02 60.4 19.8 No No
3 empty 2.42 67.9 15.5 No No
4 empty 2.09 61.2 15.3 No No
5 empty 1.67 60.6 11.4 No No
6 empty 2.17 77.3 9.9 No No
7 empty 2.06 65.6 13.5 No No
8 empty 1.83 65.7 15.6 No No
9 empty 1.58 65.5 8.4 No No
10 empty 2.57 47.2 11.9 No No
4V1O_X Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.26 75 41.8 Yes Yes
2 empty 1.47 68.3 32.9 No No
3 empty 1.36 61.7 35 No No
4 empty 1.89 64.1 28.6 No No
5 empty 1.59 54.3 14 No No
6 empty 1 64 13.9 No No
7 empty 1.49 65.7 13.3 No No
8 empty 1.48 48.8 11 No No
9 empty 1.27 45.5 12.8 No No
10 empty 2.19 56 11 No No
2HZM_B Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 69.1 45.3 Yes Yes
2 empty 2.01 57 30.3 No No
3 empty 2.3 65.4 21.3 No No
4 empty 2.19 62.2 14.4 No No
5 empty 2.38 71.1 10.9 No No
6 empty 2.27 70.4 12.4 No No
7 empty 2.41 55.1 13.8 No No
8 empty 2.19 54.4 16.1 No No
9 empty 1.52 55.4 11.3 No No
10 empty 2.55 57.7 9.8 No No
3RJ1_S Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 69.6 54.5 Yes Yes
2 empty 2.43 53.1 8.9 No No
3 empty 2.29 51.6 7.6 No No
4 empty 1.92 51.6 8.1 No No
5 empty 1.89 55 7.7 No No
6 empty 1.12 57.5 5.3 No No
7 empty 1.18 52.3 6.6 No No
8 empty 1.83 71.6 6.2 No No
9 empty 1.06 64.2 4.9 No No
4GWP_E Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 72 35.3 Yes Yes
2 empty 2.12 62.6 25.4 No No
3 empty 1.94 73.8 20.9 No No
4 empty 1.95 66.5 15.8 No No
5 empty 2.62 60.9 17.5 No No
6 empty 2.19 82.5 9.4 No No
7 empty 2.18 64.3 17.7 No No
8 empty 2.29 65 22.9 No No
9 empty 2.78 54.6 13.9 No No
10 empty 2.13 61.3 13.9 No No
5SVA_Q Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 73 44.1 Yes Yes
2 empty 2.25 60.1 29.6 No No
3 empty 1.88 67.6 15.9 No No
4 empty 2.58 59.6 20.6 No No
5 empty 2.11 82.6 9.5 No No
6 empty 2.28 65.5 19.6 No No
7 empty 2.71 51 12.9 No No
8 empty 2.1 67.6 16.7 No No
9 empty 2.41 52.3 14.9 No No
10 empty 2.11 62.6 14.2 No No
2HZS_F Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 69 48.8 Yes Yes
2 empty 2.04 62.5 25.2 No No
3 empty 2.12 64.3 15.8 No No
4 empty 1.87 60.9 21.1 No No
5 empty 2.27 65.5 13.8 No No
6 empty 2.3 57.7 14 No No
7 empty 1.96 65.8 13.3 No No
8 empty 2.53 60.5 18 No No
9 empty 2.76 56.3 12.2 No No
10 empty 1.38 66.4 10 No No
2HZS_H Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 66.8 56.6 Yes Yes
2 empty 2.24 64.7 15.2 No No
3 empty 2.12 64.2 17.1 No No
4 empty 2.36 52.7 18.9 No No
5 empty 2.16 69.5 11.2 No No
6 empty 1.43 70.5 14 No No
7 empty 2.37 51.4 12.6 No No
8 empty 1.71 63.8 11.7 No No
9 empty 1.35 63.4 11.3 No No
10 empty .74 66.5 8 No No
4GWQ_E Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 70.8 37.1 Yes Yes
2 empty 2.06 62 29.7 No No
3 empty 2.03 75.5 19.2 No No
4 empty 1.95 68.8 15.8 No No
5 empty 2.66 62 17.8 No No
6 empty 2.35 65.6 20.8 No No
7 empty 2.36 57.1 13.1 No No
8 empty 2.28 83.3 8 No No
9 empty 2.29 64.2 16.9 No No
10 empty 2.87 54.4 14.3 No No
3RJ1_E Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 70.3 51.5 Yes Yes
2 empty 2.02 52 18.3 No No
3 empty 2.33 58.5 8.6 No No
4 empty 2.28 56.4 8.3 No No
5 empty 2.27 55.2 7.6 No No
6 empty 1.85 57.6 7.4 No No
7 empty 2.51 75.6 0 No No
8 empty 1.91 75 0 No No
9 empty 1.85 71.6 5.2 No No
2HZS_B Mediator of RNA polymerase II transcription subunit 18 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 66.1 48.7 Yes No
2 empty 2.21 68.5 15.5 No No
3 empty 2.43 59.2 19.7 No No
4 empty 2.05 64.2 17.4 No No
5 empty 2.19 72.8 9.9 No No
6 empty 2.42 51.7 14.2 No No
7 empty 1.61 64.8 12.6 No No
8 empty 2.21 70 12.3 No No
9 empty 1.38 67.7 10.9 No No
10 empty .85 69.4 7.6 No No
2HZS_D Mediator of RNA polymerase II transcription subunit 18 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 66 54 Yes No
2 empty 2.55 63.5 30.5 No No
3 empty 2.16 64.3 16.8 No No
4 empty 2.04 55.8 21.1 No No
5 empty 2.31 54.6 13.6 No No
6 empty 2.39 64.7 12.3 No No
7 empty 1.33 68.5 9.9 No No
8 empty 2.03 69.6 7.4 No No
9 empty 1.95 62 7 No No
10 empty 2.47 74 4.7 No No
3J1O_L Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 70.9 51.8 Yes Yes
2 empty 1.72 63.3 24.6 No No
3 empty 1.96 55.2 18 No No
4 empty 2.35 49.7 8.8 No No
5 empty 2.37 57.3 10.2 No No
6 empty 2.14 53.5 7 No No
7 empty 1.93 57.6 5.2 No No
8 empty 2.75 68.7 5.3 No No
9 empty 1.04 68.9 0 No No
10 empty 2.04 66.7 4.8 No No
5OQM_e Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 73.3 33.5 Yes Yes
2 empty 2.01 62 28 No No
3 empty 1.93 58.3 27.4 No No
4 empty 2.26 70 15.9 No No
5 empty 2.64 60.6 19.9 No No
6 empty 2.08 68.5 18.6 No No
7 empty 2.27 54.9 18.2 No No
8 empty 2.44 53.6 14.5 No No
9 empty 2.56 63.1 11.4 No No
10 empty 1.52 71.8 10 No No
3RJ1_L Mediator of RNA polymerase II transcription subunit 18 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 70.1 54.3 Yes Yes
2 empty 2.36 57.7 7.7 No No
3 empty 2.31 50.7 7.3 No No
4 empty 2.25 52.5 7.3 No No
5 empty 1.85 58.1 6.3 No No
6 empty 1.67 66.7 5.4 No No
7 empty 2.38 76.1 0 No No
8 empty 2.14 73.3 0 No No
9 empty 1.59 69 4.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2HZM_B (3110689) Mediator of RNA polymerase II transcription subunit 18 PFAM, PFAM, PFAM Med18 2.4Å Yes Yes
2HZS_B (3110698) Mediator of RNA polymerase II transcription subunit 18 PFAM, PFAM, PFAM Med18 2.7Å Yes No
3RJ1_E (3700093) Mediator of RNA polymerase II transcription subunit 18 PFAM, PFAM, PFAM Med18 4.3Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score