Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

NAB2 (P32505) - Overview - Molecular Target Synopsis

Protein


NAB2, Nuclear polyadenylated RNA-binding protein NAB2
UniProt P32505

Also Known as NAB2_YEAST, NAB2

This essential protein binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions.

5L2L
NAB2 ZN FINGERS 5-7 BOUND TO A11G RNA
RCSB/PDB
Inspect Structure
See all 3D Structures for NAB2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
525P32505-1

Sub-cellular localization


UniProt: NAB2 is active in the following subcellular-locations: nucleus.
GO terms: NAB2 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAB2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For NAB2 there are:
8 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis