NHP2, H/ACA ribonucleoprotein complex subunit NHP2
Also Known as
Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512, PubMed:9848653). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512, PubMed:9848653). Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs (PubMed:9843512, PubMed:9848653). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9843512). Directly binds H/ACA snoRNAs (PubMed:11433018). Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (PubMed:21708174, PubMed:9843512, PubMed:9848653, PubMed:21131909). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10 (PubMed:21708174, PubMed:9843512, PubMed:9848653, PubMed:21131909). The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind (PubMed:21708174, PubMed:9843512, PubMed:9848653, PubMed:21131909). Interacts with SHQ1 (PubMed:12228251). Interacts with NAF1 (PubMed:12515383).