Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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Germline Genetics

ASF1 (P32447) - Overview - Molecular Target Synopsis

Protein


ASF1, Histone chaperone ASF1
UniProt P32447

Also Known as ASF1_YEAST, ASF1, CIA1

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Facilitates histone deposition through both replication-dependent and replication-independent chromatin assembly pathways. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with the HIR complex to promote replication-independent chromatin assembly, which may occur during transcription and DNA repair. May be required for the maintenance of a subset of replication elongation factors, including DNA polymerase epsilon, the RFC complex and PCNA, at stalled replication forks. Also required for acetylation of histone H3 on 'Lys-9' and 'Lys-56'. Interacts with histone H3/H4 heterodimers via both histone H3 and histone H4. Interacts with RAD53 and this may impair interaction with histones and chromatin assembly. Interaction with RAD53 is reduced upon activation of DNA damage or replication checkpoints and loss of RAD53 may in turn facilitate interaction with histones and chromatin assembly. Interacts with the CAC2 subunit of chromatin assembly factor 1 (CAF-1). Interacts with the HIR1, HIR2, HIR3 and HPC2 subunits of the HIR complex. Interacts with the RFC1, RFC2, RFC3, RFC4 and RFC5 subunits of the replication factor C (RF-C/RFC) complex. The RF-C complex may recruit this protein to DNA. Interacts with the SAS2, SAS4 and SAS5 subunits of the SAS/SAS-I complex. Interacts with the BDF1, BDF2, SPT15, TAF1 and TAF7 subunits of the TFIID complex. Interacts with RTT109.

6AYZ
CRYSTAL STRUCTURE OF ASF1-FAB 12E COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for ASF1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
279P32447-1

Sub-cellular localization


UniProt: ASF1 is active in the following subcellular-locations: nucleus.
GO terms: ASF1 is active in the following subcellular-locations: chromosome, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ASF1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ASF1 there are:
14 structures (21 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis