Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

psaC (P32422) - Overview - Molecular Target Synopsis

Protein


psaC, Photosystem I iron-sulfur center
Enzyme Classification 1.97.1.12
UniProt P32422

Also Known as PSAC_SYNY3, psaC

Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn., Mutant proteins with a 3Fe-4S center are unable to reconstitute PSI activity in vivo. The cyanobacterial PSI reaction center is composed of one copy each of PsaA,B,C,D,E,F,I,J,K,L,M and X, and forms trimeric complexes.

6HQB
MONOMERIC CYANOBACTERIAL PHOTOSYSTEM I
RCSB/PDB
Inspect Structure
See all 3D Structures for psaC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: psaC is active in the following subcellular-locations: cellular thylakoid membrane.
GO terms: psaC is active in the following subcellular-locations: photosystem I, thylakoid membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project psaC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For psaC there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


psaC has been screened with compounds ( bioactivities). (see details)