Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DCTD (P32321) - Overview - Molecular Target Synopsis

Protein


DCTD, Deoxycytidylate deaminase
Enzyme Classification 3.5.4.12
UniProt P32321

Also Known as DCTD_HUMAN, DCTD

Supplies the nucleotide substrate for thymidylate synthetase. Homohexamer.

2W4L
HUMAN DCMP DEAMINASE
RCSB/PDB
Inspect Structure
See all 3D Structures for DCTD

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: DCTD is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DCTD has gain in 0 cell-lines, loss in 13 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, CAKI_1, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2373, Hs 746T, SU-DHL-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For DCTD there are:
1 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DCTD has been screened with 2 compounds (6 bioactivities). (see details)