Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDA (P32320) - Overview - Molecular Target Synopsis

Protein


CDA, Cytidine deaminase
Enzyme Classification 3.5.4.5
UniProt P32320

Also Known as CDD_HUMAN, CDA, CDD

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Homotetramer.

1MQ0
CRYSTAL STRUCTURE OF HUMAN CYTIDINE DEAMINASE
RCSB/PDB
Inspect Structure
See all 3D Structures for CDA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
146ENSG00000158825ENST00000375071ENSP00000364212P32320-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project CDA has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, HOP_92, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1493, LCLC-103H, NCI-H2009

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HeLa-S3, NHEK

(see details)

3D Structures


For CDA there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDA has been screened with 59 compounds (85 bioactivities), 16 compounds have bioactivities that show binding affinity of <= 500nM (22 bioactivities). (see details)