Molecular Target Synopsis
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PRDX2 (P32119) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed40
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria22


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5IJT_G Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 77.7 17 Yes No
2 empty 2.25 65.2 21.7 No No
3 empty 2.32 71.5 12.3 No No
4 empty 2.07 59.1 14.7 No No
5 empty 1.95 63.7 18.2 No No
6 empty 2.28 66.9 12 No No
7 empty 1.64 69.5 8.5 No No
8 empty 1.9 97.7 0 Yes No
9 empty 2.35 71.6 9.5 No No
10 empty 1.77 56.3 9.9 No No
1QMV_B Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 69.2 17.6 No No
2 empty 2.17 62.4 22.3 No No
3 empty 2.36 73.4 13.7 No No
4 empty 1.87 58.5 18.1 No No
5 empty 1.75 69.1 15.3 No No
6 empty 1.18 63.9 13.3 No No
7 empty 2.27 58.6 13.6 No No
8 empty 2.33 74.1 10.2 No No
9 empty 1.63 61.9 15 No No
10 empty 2.29 63.3 11.7 No No
5B8B_H Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 60.8 23.2 No No
2 empty 2.33 59.9 13.6 No No
3 empty 2.23 75.6 9.9 No No
4 empty 1.7 57.4 11 No No
5 bound 1.64 62.9 12.6 No No
6 empty 1.61 65.5 14.8 No No
7 empty 2.03 65.8 13.7 No No
8 empty 2.17 81.3 11.4 No No
9 empty 2.11 63.2 9.6 No No
10 empty 1.9 62.1 7.2 No No
5IJT_A Peroxiredoxin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 82.6 15.3 Yes Yes
2 empty 2.31 68.6 19.6 No No
3 empty 2.45 69 16 No No
4 empty 1.79 65.9 19.6 No No
5 empty 2.24 71 15.7 No No
6 empty 2.14 55 19.5 No No
7 empty 1.91 68.3 13.6 No No
8 empty 2.33 65.5 11.4 No No
9 empty 2.5 70.8 10.4 No No
10 empty 2.4 53.8 11 No No
1QMV_C Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 71.3 27.4 Yes No
2 empty 2.29 63 25.6 No No
3 empty 2.32 68.8 14.5 No No
4 empty 1.85 62.2 17.6 No No
5 empty 2.51 64.7 16.7 No No
6 empty 2.21 59.6 13.8 No No
7 empty 1.2 66 10.3 No No
8 empty 1.67 62 14.4 No No
9 empty 2.25 69.1 9 No No
10 empty 1.93 73 10.2 No No
1QMV_G Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 61.5 19.3 No No
2 empty 2.09 67.1 22 No No
3 empty 2.26 72.5 13.3 No No
4 empty 1.85 60.6 17.4 No No
5 empty 2.16 58.3 13.4 No No
6 empty 1.21 64.9 10.3 No No
7 empty 1.79 66.9 13.9 No No
8 empty 1.53 60.8 13.5 No No
9 empty 2.6 75.9 11.4 No No
10 empty 2.27 72.6 10.1 No No
5B8B_B Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 54.2 23.2 No No
2 empty 2.11 62.9 19.1 No No
3 empty 2.25 72.8 10.8 No No
4 empty 2.27 64.6 12.8 No No
5 empty 2 68.8 12.9 No No
6 empty 1.97 58.3 12 No No
7 empty 1.62 57.3 10.7 No No
8 empty 2.24 74.2 9.7 No No
9 empty 2.6 60.2 9.3 No No
10 empty 1.91 66.5 7.4 No No
5B8B_F Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 60.4 23.8 No No
2 empty 2.36 72.2 10.6 No No
3 empty 2.47 68.7 13.5 No No
4 empty 1.46 59.2 13.7 No No
5 empty 1.93 66.6 13.7 No No
6 empty 2.38 65.1 11.7 No No
7 empty 2.38 73.1 15 No No
8 empty 2.17 79.3 11.3 No No
9 empty 1.76 64.3 11.9 No No
10 empty 2.2 59.3 8.8 No No
5B8A_H Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 55.4 24.4 Yes No
2 empty 1.81 49.8 14.2 No No
3 empty 2.27 62.6 12.1 No No
4 bound 1.69 73.7 16.4 No No
5 empty 2.04 57.8 15.3 No No
6 empty 2.2 69 11.9 No No
7 empty 2.08 67.9 15.5 No No
8 empty 1.93 64 11.7 No No
9 bound 2.26 69.9 11.8 No No
10 empty 1.86 69.4 11.8 No No
5IJT_C Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 69.6 19.6 No No
2 empty 2.3 58.6 15.6 No No
3 empty 2.16 57.5 18.2 No No
4 empty 2.22 80.9 13.9 No No
5 empty 2.22 68.9 13.1 No No
6 empty 2.13 65.9 20.3 No No
7 empty 1.79 75.6 12.4 No No
8 empty 2.42 74.9 12 No No
9 empty 2.78 67.6 9.3 No No
10 empty 2.15 68.9 7.2 No No
1QMV_F Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 62.6 21.8 No No
2 empty 2.2 60.6 20.7 No No
3 empty 2.32 72.2 14 No No
4 empty 1.91 59.8 19.9 No No
5 empty 1.21 64 13 No No
6 empty 1.66 58.3 14.1 No No
7 empty 2.08 59 13.8 No No
8 empty 2.42 73.9 11.2 No No
9 empty 2.28 65.4 12.2 No No
10 empty 1.95 73.1 11.2 No No
5B8B_A Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 59.3 23 No No
2 empty 2.35 66.8 20.1 No No
3 empty 1.98 66.1 19 No No
4 empty 2.4 63.4 15.2 No No
5 bound 1.69 61.8 10.3 No No
6 empty 2.2 73 12.3 No No
7 empty 1.62 64.2 12.2 No No
8 empty 1.85 63.8 8.6 No No
9 empty 2.11 64.3 8.6 No No
10 empty 1.5 97.5 0 Yes No
1QMV_D Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 62.6 34.2 Yes No
2 empty 2.31 66.9 20.1 No No
3 empty 1.87 58.8 18.2 No No
4 empty 2.32 71.5 14.7 No No
5 empty 1.24 61.9 12.2 No No
6 empty 2.34 58.3 13.7 No No
7 empty 1.63 58.9 14.3 No No
8 empty 2.38 62.4 12.6 No No
9 empty 1.98 78 11.4 No No
10 empty 1.9 68.9 9.8 No No
5B8B_G Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 56.3 23.7 No No
2 empty 2.11 69.3 13.6 No No
3 empty 2.38 72.1 12.2 No No
4 empty 2.02 71.3 13 No No
5 empty 2.52 66.9 13.9 No No
6 empty 2.3 70.9 13.8 No No
7 bound 1.43 59.4 10.1 No No
8 empty 2.21 62.2 8.9 No No
9 bound 1.67 63.4 10.5 No No
10 empty 2.12 60.2 10 No No
1QMV_H Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 63.6 18.6 No No
2 empty 2.25 67.5 19.4 No No
3 empty 1.88 61.3 20.1 No No
4 empty 2.26 70.5 15.2 No No
5 empty 1.21 63.1 11.2 No No
6 empty 2.12 55.4 13.8 No No
7 empty 1.71 62.4 14.6 No No
8 empty 2.32 71.5 10.7 No No
9 empty 2.29 66 10.3 No No
10 empty 2.01 75.6 9.5 No No
5B8A_I Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 56.1 22.4 No No
2 empty 2.18 63.8 18.2 No No
3 empty 2.3 69.3 12.9 No No
4 empty 1.99 71 11.8 No No
5 empty 2.25 52.9 14.9 No No
6 empty 2.54 67.4 11.4 No No
7 empty 1.75 61.5 9.1 No No
8 empty 1.92 67.1 11.9 No No
9 empty 2.32 74.2 10.6 No No
10 bound 1.62 97.8 0 Yes No
5B8B_J Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 59.2 24 Yes No
2 empty 2.3 69.4 11.6 No No
3 empty 2.4 65 13.7 No No
4 empty 1.48 55.4 12 No No
5 empty 1.68 70.8 12.6 No No
6 empty 2.37 70.9 10.1 No No
7 empty 2.44 60.8 9.7 No No
8 empty 1.74 61 11.3 No No
9 empty 2.75 58.1 12.1 No No
10 empty 2.4 56.3 11 No No
5IJT_J Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 59.8 25.9 Yes No
2 empty 2.08 72.6 19.8 No No
3 empty 2.43 65.8 13.2 No No
4 empty 2.03 61.7 18.4 No No
5 empty 2.26 74.6 9 No No
6 empty 2.05 44.4 16.5 No No
7 empty 2.11 72.8 11.3 No No
8 empty 2.41 61.4 11.2 No No
9 empty 2.77 63.4 11.3 No No
10 empty 1.84 99.3 0 Yes No
5IJT_B Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 64.6 21.9 No No
2 empty 1.92 66.9 13.4 No No
3 empty 2.3 72 13.9 No No
4 empty 1.84 62.4 19.1 No No
5 empty 2.28 79.9 14.5 No No
6 empty 1.85 31.9 14.6 No No
7 empty 2.1 60.1 18.9 No No
8 empty 1.74 73 12.6 No No
9 empty 2.57 67.6 12.7 No No
10 empty 2.44 60 15 No No
5B8A_C Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 57.3 22 No No
2 empty 1.96 51.9 16.8 No No
3 empty 2.36 73.4 11 No No
4 empty 1.75 69.9 16.2 No No
5 empty 1.85 63.5 10.9 No No
6 empty 2.28 55.7 11.3 No No
7 empty 1.79 58.7 11.3 No No
8 empty 2.03 66.3 10.9 No No
9 empty 2.21 57 8.8 No No
10 empty 2.23 68.6 9.8 No No
5B8A_G Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 56 25.2 Yes No
2 empty 1.93 63.1 17.9 No No
3 bound 1.74 59.9 15.5 No No
4 empty 2.28 67.2 13.9 No No
5 empty 1.97 68.8 11 No No
6 bound 1.72 85.1 14.4 Yes No
7 empty 1.74 56.4 12.2 No No
8 bound 2.25 70.6 13.5 No No
9 empty 2.49 64.8 11.9 No No
10 empty 2.12 56.9 10.5 No No
5B8A_A Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 59.1 20.7 No No
2 empty 1.97 54.8 18.7 No No
3 bound 1.98 71.5 24.1 No No
4 empty 2.25 64.5 18.8 No No
5 empty 2.44 65 12.5 No No
6 bound 1.84 61.7 11.9 No No
7 empty 2.14 66.1 12.8 No No
8 bound 2.34 73.6 9.6 No No
9 empty 2.24 74.3 10.4 No No
10 bound 2.09 52.4 10.7 No No
5B8A_E Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 58.8 23.9 No No
2 bound 1.68 76.7 16.6 Yes No
3 bound 2.16 56.5 21.7 No No
4 bound 1.83 68.3 10.4 No No
5 empty 2.23 72.5 14.5 No No
6 empty 2.4 65.7 10.6 No No
7 empty 1.92 67.9 16.6 No No
8 empty 2.1 67.3 11 No No
9 empty 2.2 59.8 10.9 No No
10 empty 2.12 76.8 11.5 No No
1QMV_J Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 67.3 19.4 No No
2 empty 2.22 64.1 16.1 No No
3 empty 1.9 57.8 18.9 No No
4 empty 2.23 71.4 10.5 No No
5 empty 1.19 61.9 10.7 No No
6 empty 1.54 59.7 14.2 No No
7 empty 2.16 55.4 14.7 No No
8 empty 2.44 75.4 9 No No
9 empty 2.23 63.6 12.5 No No
10 empty 2.24 67.3 9.4 No No
5IJT_F Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 53.7 23.8 No No
2 empty 2.16 67.2 16.8 No No
3 empty 1.97 64.3 16.6 No No
4 empty 2.01 65.8 19.1 No No
5 empty 2.18 70.8 12.8 No No
6 empty 1.85 85.7 10.5 Yes No
7 empty 1.76 74.7 10 No No
8 empty 2.01 100 0 Yes No
9 empty 2.15 54 11.5 No No
10 empty 3.03 48.9 9.5 No No
5B8B_C Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 62.8 22.9 No No
2 empty 1.88 57.7 19.1 No No
3 empty 2.5 67.9 16.3 No No
4 empty 1.48 61.9 10.2 No No
5 bound 2.26 72.2 11.7 No No
6 empty 2.03 68.5 13.3 No No
7 empty 2.08 72.1 11.4 No No
8 empty 1.7 60.3 8.1 No No
9 empty 1.6 53.3 9.9 No No
10 empty 1.84 80.4 9.9 No No
5B8B_I Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 55.7 22.8 No No
2 empty 2.4 69.9 12.7 No No
3 empty 2.55 60.9 14.5 No No
4 empty 1.86 67.3 13 No No
5 empty 2.03 72.8 9.3 No No
6 empty 1.68 61.3 10.1 No No
7 empty 2.26 80.1 10.5 No No
8 empty 2.16 66 11.3 No No
9 empty 1.55 60.6 8.7 No No
10 empty 2.12 58.1 8.9 No No
5B8A_B Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 56.3 24.1 Yes No
2 bound 2 61.2 13.5 No No
3 empty 1.97 57.7 17.3 No No
4 bound 2.18 74.7 11.6 No No
5 empty 2.33 67.8 11.3 No No
6 empty 1.99 67.3 10.1 No No
7 empty 2.02 70.3 12.1 No No
8 empty 2 73.5 9 No No
9 bound 1.55 100 0 Yes No
10 empty 2.45 61.5 11.3 No No
5B8A_F Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 56.7 22.6 No No
2 bound 1.62 73.3 17.1 Yes No
3 empty 2.17 63.9 19.6 No No
4 empty 2.33 72.6 12.7 No No
5 empty 2.36 67.5 11.3 No No
6 bound 2.02 60.5 12.2 No No
7 empty 2.06 69.3 13.6 No No
8 empty 2.02 68.7 12.6 No No
9 empty 2.19 76.5 11.1 No No
10 empty 2.2 58.5 8.9 No No
5B8B_D Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 55.1 22.2 No No
2 empty 2.13 72 12.6 No No
3 empty 2.41 66.4 14.2 No No
4 empty 2.02 70.9 12.8 No No
5 empty 1.69 60.2 9.1 No No
6 empty 2.11 58.6 12.3 No No
7 bound 1.57 58.9 11.5 No No
8 empty 1.98 69.1 12 No No
9 empty 2.25 71.2 11.6 No No
10 bound 2.11 57.1 10.1 No No
5B8A_J Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 53.4 19.9 No No
2 empty 2.1 58.6 22 No No
3 empty 2 65.8 17.5 No No
4 empty 2.53 67.4 15.5 No No
5 empty 2.3 68.5 12.9 No No
6 bound 1.96 61.9 10.8 No No
7 bound 1.81 67.2 14.9 No No
8 bound 1.75 56 11.3 No No
9 bound 2.11 70.6 8.2 No No
10 bound 1.67 99.4 0 Yes No
1QMV_A Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 62.3 19.7 No No
2 empty 2.45 64.8 24.4 No No
3 empty 2.34 68.5 16 No No
4 empty 1.89 60.9 17.8 No No
5 empty 1.41 68.3 10.7 No No
6 empty 1.68 61.9 14.4 No No
7 empty 2.38 68.6 12.4 No No
8 empty 2.2 58.1 13.4 No No
9 empty 2.3 68.1 11.1 No No
10 empty 2.01 71 12.1 No No
5IJT_E Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 53.6 24.1 Yes No
2 empty 2.27 64.7 23.7 No No
3 empty 1.86 55.3 16.9 No No
4 empty 2.01 70.1 19.8 No No
5 empty 1.9 75.1 15.6 No No
6 empty 2.23 70.1 16.9 No No
7 empty 2.13 45.5 16.4 No No
8 empty 2.76 56.5 12.2 No No
9 empty 1.96 97 0 Yes No
10 empty 2.02 64.4 12.5 No No
5B8A_D Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 56.4 22.4 No No
2 bound 2.09 72.9 13.2 No No
3 empty 1.73 54 17.7 No No
4 empty 2.22 75.2 11.5 No No
5 empty 1.7 67.2 14.7 No No
6 empty 1.54 60.1 9.8 No No
7 bound 2.12 63.2 8.6 No No
8 empty 2.31 63.5 9.5 No No
9 empty 2.22 74 10.6 No No
10 bound 1.85 99.4 0 Yes No
5B8B_E Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 56.7 24.2 Yes No
2 bound 2.29 72.3 13.8 No No
3 empty 1.73 68.6 13.9 No No
4 bound 1.63 61.8 12.1 No No
5 empty 2 64.1 9.4 No No
6 empty 2.39 65.8 8.9 No No
7 empty 1.84 59.8 10.6 No No
8 empty 2.24 74.2 11 No No
9 empty 1.9 58.3 9.7 No No
10 empty 2.11 67.7 7.3 No No
5IJT_I Peroxiredoxin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 55.1 22.8 No No
2 empty 2.22 63.6 27.3 No No
3 empty 1.93 70.6 21.8 No No
4 empty 2.34 66.9 16.1 No No
5 empty 2.19 81.9 14.2 No No
6 empty 2.33 58.7 19.9 No No
7 empty 1.79 66.3 17.5 No No
8 empty 1.83 46.3 13.5 No No
9 empty 1.96 56.6 15.9 No No
10 empty 2.45 65.9 10.3 No No
5IJT_H Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 55.7 25.7 Yes No
2 empty 2.28 65.4 27.7 No No
3 empty 1.77 79.5 14.7 No No
4 empty 2.41 66.4 20 No No
5 empty 1.78 64.9 18.7 No No
6 empty 1.61 68.4 13.4 No No
7 empty 2.63 64.6 9.5 No No
8 empty 2 73.8 7.9 No No
9 empty 2.29 54.9 12.8 No No
10 empty 2.43 76.8 10.7 No No
5IJT_D Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 72.9 17.6 Yes No
2 empty 2.3 68.7 14.3 No No
3 empty 2.21 65 16.8 No No
4 empty 2 64.3 20.4 No No
5 empty 2.39 78.2 14 No No
6 empty 1.88 62.6 15.1 No No
7 empty 2.35 52.3 12.4 No No
8 empty 2.86 65.6 10.9 No No
9 empty 2.29 58.4 9.4 No No
10 empty 2.13 54.7 8.3 No No
1QMV_I Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 59.6 26.4 Yes No
2 empty 2.33 65.3 19.5 No No
3 empty 2.29 72.7 15.1 No No
4 empty 1.87 59.8 18.6 No No
5 empty 1.21 68.3 8.2 No No
6 empty 1.68 65.1 14 No No
7 empty 2.15 62 13.2 No No
8 empty 1.63 72.4 13.3 No No
9 empty 2.2 63.7 11.8 No No
10 empty 2.51 66.2 8.9 No No
1QMV_E Peroxiredoxin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 59.7 27.4 Yes No
2 empty 2.47 68.2 21.2 No No
3 empty 2.28 67.8 18.7 No No
4 empty 2.49 64 17.5 No No
5 empty 1.92 58.2 17.5 No No
6 empty 2.01 57.7 12.9 No No
7 empty 1.22 65.3 10.5 No No
8 empty 1.71 65.2 16.7 No No
9 empty 1.68 65.5 13 No No
10 empty 2.12 67.7 11.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed10
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1QMV_A (33066) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å No No
1QMV_B (33067) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å No No
1QMV_C (33068) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å Yes No
1QMV_D (33069) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å Yes No
1QMV_J (33075) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å No No
1QMV_F (33071) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å No No
1QMV_G (33072) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å No No
1QMV_H (33073) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å No No
1QMV_I (33074) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å Yes No
1QMV_E (33070) Peroxiredoxin-2 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 1.7Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PRDX2 is involved in 25 interactions in the network.


Druggability
Overall Druggability Percentile: 80.10
Druggability for Cancer Therapeutics: 81.29
Druggability for Other Therapeutics: 86.16
Cancer-Associated
Cancer-associated percentile : 77.56
Network Articulation Point
Is PRDX2 critical for communication in the network?


Detailed Graph Legend:Help