Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Expression
Gene Copy Number Variation
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fcl (P32055) - Overview - Molecular Target Synopsis

Protein


fcl, GDP-L-fucose synthase
Enzyme Classification 1.1.1.271
UniProt P32055

Also Known as FCL_ECOLI, fcl, wcaG, yefB

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Homodimer.

1E6U
GDP 4-KETO-6-DEOXY-D-MANNOSE EPIMERASE REDUCTASE
RCSB/PDB
Inspect Structure
See all 3D Structures for fcl

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
321P32055-1

Sub-cellular localization


UniProt: fcl is active in the following subcellular-locations: cytoplasm.
GO terms: fcl is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project fcl has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fcl there are:
8 structures (8 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis