Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

APOBEC3A (P31941) - Overview - Molecular Target Synopsis

Protein


APOBEC3A, DNA dC->dU-editing enzyme APOBEC-3A
Enzyme Classification 3.5.4.38
UniProt P31941

Also Known as ABC3A_HUMAN, APOBEC3A

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Interacts with AGO2. Interacts with TRIB3 (via N-terminus).

5KEG
CRYSTAL STRUCTURE OF APOBEC3A IN COMPLEX WITH A SINGLE-STRANDED DNA
RCSB/PDB
Inspect Structure
See all 3D Structures for APOBEC3A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
199ENSG00000128383ENST00000249116, ENST00000402255ENSP00000249116, ENSP00000384359P31941-1
187P31941-2

Sub-cellular localization


UniProt: APOBEC3A is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: APOBEC3A is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project APOBEC3A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BICR 22, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, SK-N-SH, NHLF

(see details)

3D Structures


For APOBEC3A there are:
4 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


APOBEC3A has been screened with 1 compounds (2 bioactivities). (see details)