Molecular Target Synopsis
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metI (P31547) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed16
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria16


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6CVL_A D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.05 66.4 25.5 Yes No
2 empty .84 69.2 22.1 No No
3 empty 2.05 63.8 21.8 No No
4 empty 1.35 63.7 20.3 No No
5 empty 2.46 65.9 13.3 No No
6 empty 1.59 76.6 13.7 No No
7 empty 2.38 72.5 10.3 No No
8 empty 2.21 61.7 10.8 No No
9 empty 2.18 58 11.2 No No
10 empty .87 62.4 10.5 No No
3TUI_E D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 65 25.5 Yes No
2 empty 1.1 60.6 28.6 No No
3 empty 1.19 61.1 20.4 No No
4 empty .82 65.8 19.9 No No
5 empty 1.24 61.8 25.1 No No
6 empty 2.15 68.9 12.5 No No
7 empty 2.05 54.4 15.9 No No
8 empty 2.52 69.8 11 No No
9 empty 1.17 63.7 17.9 No No
10 empty 2.08 61.3 9.7 No No
3TUI_A D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 57.5 26.9 Yes No
2 empty 1.12 67.4 21.9 No No
3 empty .71 70.6 27.8 No No
4 empty 1.34 64.1 17.8 No No
5 empty 1.09 59.6 24.2 No No
6 empty 2.47 67.8 19.9 No No
7 empty 2.27 70.4 12.9 No No
8 empty 1.95 69.9 12 No No
9 empty 2.02 70.9 8.1 No No
10 empty 2.27 56 12.7 No No
3TUJ_B D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 63.3 30.2 Yes No
2 empty 1.43 62.8 32 No No
3 empty .57 66.7 35.2 No No
4 empty 2.48 65.1 21.8 No No
5 empty 1.02 63.7 24.1 No No
6 empty 2.18 53.6 16.7 No No
7 empty .38 76.1 9.9 No No
8 empty 1.77 62.2 14.8 No No
9 empty .87 65.5 11.6 No No
10 empty 1.62 79.6 8.1 No No
3TUJ_A D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.12 67.7 26 Yes No
2 empty 1.45 64.9 34.6 No No
3 empty 1.09 63.2 24.2 No No
4 empty 2.3 62.7 22.1 No No
5 empty .19 77.6 9 No No
6 empty 2.34 60.6 16.2 No No
7 empty 2.22 60.6 13.3 No No
8 empty 1.95 75 10.7 No No
9 empty 1.23 53.8 9.1 No No
10 empty .55 56.1 10.3 No No
6CVL_B D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .88 65.9 28.8 Yes No
2 empty .8 69.3 22.5 No No
3 empty 2.13 62.2 22 No No
4 empty 1.43 61.1 17.6 No No
5 empty 1.6 79.1 11.8 No No
6 empty 2.4 69.7 12.2 No No
7 empty 2.39 79.8 9.6 No No
8 empty 2.09 60.6 12.2 No No
9 empty 2.14 59.4 11.9 No No
10 empty .77 65.5 10.8 No No
3TUZ_A D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 56.7 27.6 Yes No
2 empty .49 70.2 22.5 No No
3 empty 1.35 62.1 19.5 No No
4 empty 1.22 63.4 23.4 No No
5 empty 1.36 71.3 16.4 No No
6 empty 1.78 59.6 23.3 No No
7 empty 2.57 72.4 14.8 No No
8 empty .32 68.7 11.2 No No
9 empty .59 82.3 8.8 No No
10 empty 2.11 70.2 9.6 No No
3TUZ_B D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.26 64.9 34.5 Yes No
2 empty 2.4 61.6 27 No No
3 empty 2.05 63.1 27.7 No No
4 empty 1.09 68.6 21.4 No No
5 empty 1.07 60.9 22.6 No No
6 empty 2.37 69.1 15.5 No No
7 empty 2.16 64.1 13.9 No No
8 empty 2.01 56.7 13.3 No No
9 empty 2.11 81.6 11.6 No No
10 empty .89 65.7 8.5 No No
3DHW_A D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.02 71 42.8 Yes No
2 empty 1.33 68.7 33.6 No No
3 empty .99 60.1 27 No No
4 empty 1.91 55.2 17.3 No No
5 empty 1.6 63.4 11.2 No No
6 empty 2.12 65.9 16.2 No No
7 empty 1.98 62.1 13.6 No No
8 empty .15 75.6 9.8 No No
9 empty 2.32 71.2 8.2 No No
10 empty 1.66 70 11.6 No No
3TUI_B D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.17 63.8 27.4 Yes No
2 empty 2.32 61.9 24.8 No No
3 empty .72 71.3 21.7 No No
4 empty 1.22 61.4 24.6 No No
5 empty 1.9 68.8 17 No No
6 empty 2.43 66.2 14.5 No No
7 empty 2.03 58.8 12 No No
8 empty .96 67 10.6 No No
9 empty 1.95 55.5 13.7 No No
10 empty 2.06 74.6 10.7 No No
3DHW_B D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.16 64.5 37 Yes No
2 empty .97 69.8 55.6 No No
3 empty 1.31 79.1 13.4 No No
4 empty 2.33 72.9 13.5 No No
5 empty 2.17 60.7 20.4 No No
6 empty .31 78.1 7.5 No No
7 empty 1.61 61.8 13.1 No No
8 empty 2.35 60 9 No No
9 empty .94 67.7 7.3 No No
10 empty .68 65.5 7 No No
3DHW_F D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.04 67.6 33.9 Yes No
2 empty 1.43 73.9 28.4 Yes No
3 empty 1.65 67.6 22.3 No No
4 empty 1.17 59.5 25.1 No No
5 empty 1.48 82.5 20.4 No No
6 empty 1.02 65.7 36.1 No No
7 empty 1.5 97.6 0 Yes No
8 empty 2.36 77.9 9.5 No No
9 empty 2.08 64.6 18.1 No No
10 empty 2.2 59.4 13.8 No No
3TUZ_F D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .84 68.2 32.4 Yes No
2 empty 2.23 62.6 25 No No
3 empty 1.15 65.5 23.3 No No
4 empty 1.11 60.8 25.2 No No
5 empty 2.67 70.4 12.9 No No
6 empty .21 77.9 9 No No
7 empty 2.07 63.2 13.9 No No
8 empty 2.14 58.3 15.1 No No
9 empty .87 65.4 9.7 No No
10 empty 1.7 60.3 10.5 No No
3TUI_F D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .51 69.6 26 Yes No
2 empty 2.2 60.3 25.8 No No
3 empty .19 68.8 31.8 No No
4 empty .9 59.6 24.2 No No
5 empty 2.19 58.8 18.7 No No
6 empty 2.1 62.6 14.1 No No
7 empty 1.82 72.2 16.4 No No
8 empty .7 62.6 13.6 No No
9 empty 2.72 67.6 13.6 No No
10 empty .94 69.5 12.5 No No
3DHW_E D-methionine transport system permease protein MetI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .93 74.4 40.2 Yes Yes
2 empty 1.4 65.3 22.6 No No
3 empty 1.12 68 26.5 No No
4 empty 1.93 60.7 17.8 No No
5 empty 1.84 58.3 16.2 No No
6 empty .71 71.7 10.2 No No
7 empty .58 66.1 18.3 No No
8 empty 1.06 67.8 15.7 No No
9 empty 2.07 60.8 18.1 No No
10 empty 2.2 68.9 8.5 No No
3TUZ_E D-methionine transport system permease protein MetI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.26 63.4 34.5 Yes No
2 empty 1.06 62.4 23.2 No No
3 empty 1.04 63.2 24.8 No No
4 empty 2.07 63.4 17.7 No No
5 empty 1.83 60.5 14.3 No No
6 empty 2.07 53.7 17.3 No No
7 empty .22 74 10.6 No No
8 empty 1.54 71.3 12.6 No No
9 empty 2.1 64.3 9.7 No No
10 empty 1.9 53.2 14.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3DHW_A (157727) D-methionine transport system permease protein MetI MetI-like, MetI-like, MetI-like 3.7Å Yes No
3DHW_F (157734) D-methionine transport system permease protein MetI MetI-like, MetI-like, MetI-like 3.7Å Yes No
3DHW_E (157733) D-methionine transport system permease protein MetI MetI-like, MetI-like, MetI-like 3.7Å Yes Yes
3DHW_B (157728) D-methionine transport system permease protein MetI MetI-like, MetI-like, MetI-like 3.7Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score