Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

metI (P31547) - Overview - Molecular Target Synopsis

Protein


metI, D-methionine transport system permease protein MetI
UniProt P31547

Also Known as METI_ECOLI, metI, yaeE

Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane., (Microbial infection) Probably transports the toxic C-terminal region of CdiA from E.coli strain MHI813 across the inner membrane to the cytoplasm, where CdiA has a toxic effect. Toxin transport is strain-specific, mutations in this gene do not confer resistance to several other tested CdiA toxins.

6CVL
CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ATPGS-BOUND METNI METHIONINE ABC TRANSPORTER IN COMPLEX WITH ITS METQ BINDING PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for metI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
217P31547-1

Sub-cellular localization


UniProt: metI is active in the following subcellular-locations: cell inner membrane.
GO terms: metI is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project metI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For metI there are:
5 structures (16 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis