Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXD11 (P31277) - Overview - Molecular Target Synopsis

Protein


HOXD11, Homeobox protein Hox-D11
UniProt P31277

Also Known as HXD11_HUMAN, HOXD11, HOX4F

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
338ENSG00000128713ENST00000249504ENSP00000249504P31277-1

Sub-cellular localization


UniProt: HOXD11 is active in the following subcellular-locations: nucleus.
GO terms: HOXD11 is active in the following subcellular-locations: nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXD11 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: 786_0, SNB_19, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-ES-1, DMS 454, A-673

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to HOXD11 there are:
36 structures (58 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXD11 has been screened with compounds ( bioactivities). (see details)