Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXC13 (P31276) - Overview - Molecular Target Synopsis

Protein


HOXC13, Homeobox protein Hox-C13
UniProt P31276

Also Known as HXC13_HUMAN, HOXC13, HOX3G

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
330ENSG00000123364ENST00000243056ENSP00000243056P31276-1

Sub-cellular localization


UniProt: HOXC13 is active in the following subcellular-locations: nucleus.
GO terms: HOXC13 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXC13 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, KM12, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1651, PANC-1, MFM-223

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, MCF-7, A549

(see details)

3D Structures


At greater than 90% identity similarity to HOXC13 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXC13 has been screened with compounds ( bioactivities). (see details)