Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXC9 (P31274) - Overview - Molecular Target Synopsis

Protein


HOXC9, Homeobox protein Hox-C9
UniProt P31274

Also Known as HXC9_HUMAN, HOXC9, HOX3B

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Interacts with Geminin/GMNN, which inhibits transcriptional activity.

2MSY
SOLUTION STRUCTURE OF HOX HOMEODOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for HOXC9

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
260ENSG00000180806ENST00000508190, ENST00000303450ENSP00000423861, ENSP00000302836P31274-1

Sub-cellular localization


UniProt: HOXC9 is active in the following subcellular-locations: nucleus.
GO terms: HOXC9 is active in the following subcellular-locations: aggresome, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXC9 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, T47D, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1792, AN3 CA, NCI-H1155

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For HOXC9 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXC9 has been screened with compounds ( bioactivities). (see details)