Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXA13 (P31271) - Overview - Molecular Target Synopsis

Protein


HOXA13, Homeobox protein Hox-A13
UniProt P31271

Also Known as HXA13_HUMAN, HOXA13, HOX1J

Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds DNA as a homodimer. Interacts with MEIS1, MEIS2 and MEIS3.

2L7Z
NMR STRUCTURE OF A13 HOMEDOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for HOXA13

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
388ENSG00000106031ENST00000222753ENSP00000222753P31271-1

Sub-cellular localization


UniProt: HOXA13 is active in the following subcellular-locations: nucleus.
GO terms: HOXA13 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXA13 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, HT29, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT4, PA-TU-8988S, DV-90

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For HOXA13 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXA13 has been screened with compounds ( bioactivities). (see details)