Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HOXA11 (P31270) - Overview - Molecular Target Synopsis


HOXA11, Homeobox protein Hox-A11
UniProt P31270

Also Known as HXA11_HUMAN, HOXA11, HOX1I

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HOXA11 is active in the following subcellular-locations: nucleus.
GO terms: HOXA11 is active in the following subcellular-locations: nucleoplasm, protein-containing complex, protein-DNA complex, transcription factor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HOXA11 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: A498, HT29, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-45, LS1034, HT-29

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, SK-N-SH, NHLF

(see details)

3D Structures

At greater than 50% identity similarity to HOXA11 there are:
37 structures (59 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HOXA11 has been screened with compounds ( bioactivities). (see details)