Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXA11 (P31270) - Overview - Molecular Target Synopsis

Protein


HOXA11, Homeobox protein Hox-A11
UniProt P31270

Also Known as HXA11_HUMAN, HOXA11, HOX1I

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
313ENSG00000005073ENST00000006015ENSP00000006015P31270-1
288ENSG00000005073ENST00000517402ENSP00000448962

Sub-cellular localization


UniProt: HOXA11 is active in the following subcellular-locations: nucleus.
GO terms: HOXA11 is active in the following subcellular-locations: nucleoplasm, protein-containing complex, protein-DNA complex, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXA11 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, HT29, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-45, LS1034, HT-29

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to HOXA11 there are:
37 structures (59 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXA11 has been screened with compounds ( bioactivities). (see details)