Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXA9 (P31269) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Hox9 activation region (3%), Homeodomain (100%) (view alignment) Abd-B (P09087) exd (P40427) FRUIT FLY 5ZJQ_A 61.25 7.0E-21 2.44Å - 2018-08-29
Homeodomain (99%) (view alignment) CDX2 (Q99626) - HUMAN 6ES2_L 60.66 8.0E-15 2.95Å - 2018-03-21
Homeodomain (100%) (view alignment) PDX1 (P70118) - GOLDEN HAMSTER 2H1K_A 66.1 4.0E-17 2.42Å - 2007-03-20
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 5JLW_A 69.49 2.0E-17 2.088Å - 2016-06-22
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EDN_J 50.82 2.0E-12 3.2Å - 2016-11-09
Homeodomain (95%) (view alignment) HOXB1 (P14653) PBX1 (P40424) HUMAN 1B72_A 60.34 3.0E-13 2.35Å - 1999-02-19
Homeodomain (100%) (view alignment) GBX1 (Q14549) - HUMAN 2M34_A 52.54 5.0E-11 - 2013-01-23
Homeodomain (99%) (view alignment) CDX2 (Q99626) - HUMAN 6ES2_K 60.66 8.0E-15 2.95Å - 2018-03-21
Homeodomain (100%) (view alignment) HOXB13 (Q92826) MEIS2 (O14770) HUMAN 5EG0_B 51.72 3.0E-12 2.97Å - 2016-11-09
Homeodomain (100%) (view alignment) Ubx (P83949) exd (P40427) FRUIT FLY 1B8I_A 70.18 7.0E-17 2.4Å - 1999-04-12
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 4XID_D 69.49 2.0E-17 2.7Å - 2015-11-25
Homeodomain (100%) (view alignment) Ubx (P83949) - FRUIT FLY 4UUT_A 70.18 4.0E-16 2.8Å - 2015-02-18
Homeodomain (100%) (view alignment) Scr (P09077) exd (P40427) FRUIT FLY 2R5Z_A 68.85 6.0E-18 2.6Å - 2008-02-05
Homeodomain (100%) (view alignment) Hoxa9 (P09631) PBX1 (P40424) HOUSE MOUSE 1PUF_A 100 5.0E-41 1.9Å - 2003-09-02
Homeodomain (99%) (view alignment) CDX1 (P47902) - HUMAN 5LUX_K 62.71 2.0E-14 3.23Å - 2017-05-17
Homeodomain (100%) (view alignment) HOXB13 (Q92826) TEAD4 (Q15561) HUMAN 5NO6_A 51.72 2.0E-12 2.88Å - 2018-05-16
Homeodomain (100%) (view alignment) GBX1 (Q14549) - HUMAN 2ME0_A 52.54 5.0E-11 - 2013-10-02
Hox9 activation region (3%), Homeodomain (100%) (view alignment) Abd-B (P09087) exd (P40427) FRUIT FLY 5ZJT_E 61.25 7.0E-21 2.4Å - 2018-08-29
Hox9 activation region (3%), Homeodomain (100%) (view alignment) Abd-B (P09087) exd (P40427) FRUIT FLY 5ZJS_A 61.25 7.0E-21 2.896Å - 2018-08-29
Homeodomain (100%) (view alignment) HOXA13 (P31271) - HUMAN 2L7Z_A 53.97 3.0E-14 - 2011-11-09
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 2CRA_A 52.54 2.0E-13 - 2005-11-20
Homeodomain (100%) (view alignment) Ubx (P83949) exd (P40427) FRUIT FLY 4CYC_A 70.18 4.0E-16 2.36Å - 2015-02-18
Homeodomain (100%) (view alignment) Ubx (P83949) exd (P40427) FRUIT FLY 4UUS_A 70.18 5.0E-17 2.55Å - 2015-02-18
Homeodomain (100%) (view alignment) Antp (Q24645) - FRUIT FLY 1AHD_P 65.62 1.0E-17 - 1993-10-31
Hox9 activation region (3%), Homeodomain (100%) (view alignment) Abd-B (P09087) exd (P40427) FRUIT FLY 5ZJR_A 61.25 7.0E-21 3.03Å - 2018-08-29
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 9ANT_B 69.49 3.0E-17 2.4Å - 1998-10-14
Hox9 activation region (3%), Homeodomain (100%) (view alignment) Abd-B (P09087) exd (P40427) FRUIT FLY 5ZJT_A 61.25 7.0E-21 2.4Å - 2018-08-29
Homeodomain (100%) (view alignment) HOXB13 (Q92826) MEIS1 (O00470) HUMAN 5EGO_B 51.72 2.0E-12 2.54Å - 2016-11-09
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EEA_B 51.72 2.0E-12 2.19Å - 2016-10-26
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 4XID_A 69.49 2.0E-17 2.7Å - 2015-11-25
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EF6_J 51.72 2.0E-12 2.98Å - 2017-02-08
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EF6_G 51.72 2.0E-12 2.98Å - 2017-02-08
Homeodomain (100%) (view alignment) Scr (P09077) exd (P40427) FRUIT FLY 2R5Y_A 68.85 6.0E-18 2.6Å - 2008-02-05
Homeodomain (99%) (view alignment) CDX2 (Q99626) - HUMAN 5LTY_M 60.66 9.0E-15 2.66Å - 2017-05-31
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 5JLX_A 69.49 2.0E-17 2.748Å - 2016-06-22
Homeodomain (100%) (view alignment) (Q7KSY7) - FRUIT FLY 2HOA_A 65.62 1.0E-17 - 1993-10-31
Homeodomain (100%) (view alignment) HOXC9 (P31274) - HUMAN 2MSY_A 94.12 5.0E-34 - 2015-09-16
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 4XIC_D 69.49 2.0E-17 2.69Å - 2015-11-25
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 5JLW_D 69.49 2.0E-17 2.088Å - 2016-06-22
Homeodomain (100%) (view alignment) CDX2 (Q99626) - HUMAN 6ES3_M 58.46 3.0E-15 2.18Å - 2018-03-21
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EEA_G 51.72 2.0E-12 2.19Å - 2016-10-26
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EEA_J 51.72 2.0E-12 2.19Å - 2016-10-26
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EEA_A 51.72 2.0E-12 2.19Å - 2016-10-26
Homeodomain (100%) (view alignment) CDX2 (Q99626) - HUMAN 6ES3_K 58.46 3.0E-15 2.18Å - 2018-03-21
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EDN_B 50.82 2.0E-12 3.2Å - 2016-11-09
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EDN_A 50.82 2.0E-12 3.2Å - 2016-11-09
Homeodomain (99%) (view alignment) CDX2 (Q99626) - HUMAN 5LTY_K 60.66 9.0E-15 2.66Å - 2017-05-31
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EDN_G 50.82 2.0E-12 3.2Å - 2016-11-09
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 1HOM_A 65.62 2.0E-17 - 1993-10-31
Homeodomain (100%) (view alignment) Ubx (P83949) exd (P40427) FRUIT FLY 4UUS_E 70.18 5.0E-17 2.55Å - 2015-02-18
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 4XIC_A 69.49 2.0E-17 2.69Å - 2015-11-25
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 5JLX_D 69.49 2.0E-17 2.748Å - 2016-06-22
Homeodomain (100%) (view alignment) Hoxa13 (Q62424) - MOUSE 2LD5_A 53.97 4.0E-14 - 2011-08-10
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EF6_B 51.72 2.0E-12 2.98Å - 2017-02-08
Homeodomain (100%) (view alignment) HOXB13 (Q92826) - HUMAN 5EF6_A 51.72 2.0E-12 2.98Å - 2017-02-08
Homeodomain (90%) (view alignment) Antp (P02833) - FRUIT FLY 1SAN_A 70.69 2.0E-17 - 1994-04-30
Homeodomain (99%) (view alignment) CDX1 (P47902) - HUMAN 5LUX_L 62.71 2.0E-14 3.23Å - 2017-05-17
Homeodomain (100%) (view alignment) HOXB13 (Q92826) TEAD4 (Q15561) HUMAN 5NO6_B 51.72 2.0E-12 2.88Å - 2018-05-16
Homeodomain (100%) (view alignment) ftz (P02835) - FRUIT FLY 1FTZ_A 60.61 1.0E-15 - 1994-05-31
Homeodomain (100%) (view alignment) Antp (P02833) - FRUIT FLY 9ANT_A 69.49 3.0E-17 2.4Å - 1998-10-14
Homeodomain (100%) (view alignment) PDX1 (P70118) - GOLDEN HAMSTER 2H1K_B 66.1 4.0E-17 2.42Å - 2007-03-20
Homeodomain (100%) (view alignment) HOXC9 (P31274) GMNN (O75496) HUMAN 2LP0_A 95 6.0E-29 - 2012-06-06
Homeodomain (100%) (view alignment) GBX1 (Q14549) - HUMAN 2ME6_A 52.54 5.0E-11 - 2013-10-30