Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXA9 (P31269) - Overview - Molecular Target Synopsis

Protein


HOXA9, Homeobox protein Hox-A9
UniProt P31269

Also Known as HXA9_HUMAN, HOXA9, HOX1G

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
272ENSG00000078399ENST00000343483ENSP00000343619P31269-1
106ENSG00000078399ENST00000396345ENSP00000379634

Sub-cellular localization


UniProt: HOXA9 is active in the following subcellular-locations: nucleus.
GO terms: HOXA9 is active in the following subcellular-locations: nucleus, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXA9 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, UO_31, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-22H, HM7, HCA-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, NHEK, CD34-positive mobilized cell

(see details)

3D Structures


For HOXA9 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXA9 has been screened with compounds ( bioactivities). (see details)