Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HOXA9 (P31269) - Overview - Molecular Target Synopsis


HOXA9, Homeobox protein Hox-A9
UniProt P31269

Also Known as HXA9_HUMAN, HOXA9, HOX1G

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HOXA9 is active in the following subcellular-locations: nucleus.
GO terms: HOXA9 is active in the following subcellular-locations: nucleus, transcription factor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HOXA9 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: ACHN, UO_31, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-22H, HM7, HCA-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, NHEK, CD34-positive mobilized cell

(see details)

3D Structures

For HOXA9 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HOXA9 has been screened with compounds ( bioactivities). (see details)