Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HOXA10 (P31260) - Overview - Molecular Target Synopsis


HOXA10, Homeobox protein Hox-A10
UniProt P31260

Also Known as HXA10_HUMAN, HOXA10, HOX1H

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Interacts with SIRT2; the interaction is direct.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HOXA10 is active in the following subcellular-locations: nucleus.
GO terms: HOXA10 is active in the following subcellular-locations: cytoplasm, nucleus, transcription factor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HOXA10 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: A498, HT29, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CAL51, OCI-AML3, SCLC-22H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, BJ, SK-N-SH

(see details)

3D Structures

At greater than 75% identity similarity to HOXA10 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HOXA10 has been screened with compounds ( bioactivities). (see details)