Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXA10 (P31260) - Overview - Molecular Target Synopsis

Protein


HOXA10, Homeobox protein Hox-A10
UniProt P31260

Also Known as HXA10_HUMAN, HOXA10, HOX1H

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Interacts with SIRT2; the interaction is direct.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
410ENSG00000253293ENST00000283921ENSP00000283921P31260-1
94ENSG00000253293ENST00000396344ENSP00000379633P31260-2

Sub-cellular localization


UniProt: HOXA10 is active in the following subcellular-locations: nucleus.
GO terms: HOXA10 is active in the following subcellular-locations: cytoplasm, nucleus, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXA10 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, HT29, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CAL51, OCI-AML3, SCLC-22H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, BJ, SK-N-SH

(see details)

3D Structures


At greater than 75% identity similarity to HOXA10 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXA10 has been screened with compounds ( bioactivities). (see details)