Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NTS (P30990) - Overview - Molecular Target Synopsis

Protein


NTS, Neurotensin/neuromedin N
UniProt P30990

Also Known as NEUT_HUMAN, NTS

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. Interacts with NTSR1. Interacts with SORT1.

5LUZ
4 RESIDUE FRAGMENT OF
PRO-ARG-ARG-PRO NEUROTENSIN FRAGMENTNEUROLYSIN
IN THE STRUCTURE OF
STRUCTURE OF HUMAN NEUROLYSIN (E475Q) IN COMPLEX WITH NEUROTENSIN PEPTIDE PRODUCTS
RCSB/PDB
Inspect Structure
See all 3D Structures for NTS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
170ENSG00000133636ENST00000256010ENSP00000256010P30990-1
95ENSG00000133636ENST00000551529ENSP00000448328

Sub-cellular localization


UniProt: NTS is active in the following subcellular-locations: cytoplasmic vesicle, secreted, secretory vesicle.
GO terms: NTS is active in the following subcellular-locations: axon terminus, extracellular region, transport vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NTS has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, OVCAR_8, A549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, PLC/PRF/5, NCI-H146

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, NHLF, HSMM

(see details)

3D Structures


For NTS there are:
9 structures (13 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis