CHRNB4 (P30926) - Overview - Molecular Target Synopsis
CHRNB4, Neuronal acetylcholine receptor subunit beta-4
Also Known as ACHB4_HUMAN, CHRNB4
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The pentamer alpha3-beta-4 interacts with the conotoxin BuIA (By similarity). The heteropentamer composed of alpha-3 and beta-4 subunits interacts with the alpha-conotoxin ImI (PubMed:15609996).
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UniProt: CHRNB4 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: CHRNB4 is active in the following subcellular-locations: acetylcholine-gated channel complex, cell junction, cholinergic synapse, integral component of membrane, integral component of plasma membrane, neuron projection, plasma membrane, postsynaptic membrane, specific granule membrane, synapse, tertiary granule membrane.