Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CHRNB4 (P30926) - Overview - Molecular Target Synopsis

Protein


CHRNB4, Neuronal acetylcholine receptor subunit beta-4
UniProt P30926

Also Known as ACHB4_HUMAN, CHRNB4

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The pentamer alpha3-beta-4 interacts with the conotoxin BuIA (By similarity). The heteropentamer composed of alpha-3 and beta-4 subunits interacts with the alpha-conotoxin ImI (PubMed:15609996).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CHRNB4 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: CHRNB4 is active in the following subcellular-locations: acetylcholine-gated channel complex, cell junction, cholinergic synapse, integral component of membrane, integral component of plasma membrane, neuron projection, plasma membrane, postsynaptic membrane, specific granule membrane, synapse, tertiary granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CHRNB4 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, UACC_62, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, NCI-H1155, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH_RA, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 90% identity similarity to CHRNB4 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CHRNB4 has been screened with 876 compounds (1988 bioactivities), 205 compounds have bioactivities that show binding affinity of <= 500nM (303 bioactivities). (see details)