Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC7A1 (P30825) - Overview - Molecular Target Synopsis


SLC7A1, High affinity cationic amino acid transporter 1
UniProt P30825

Also Known as CTR1_HUMAN, SLC7A1, ATRC1, ERR, REC1L

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: SLC7A1 is active in the following subcellular-locations: cell membrane.
GO terms: SLC7A1 is active in the following subcellular-locations: integral component of plasma membrane, membrane, plasma membrane, protein-containing complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC7A1 has gain in 3 cell-lines, loss in 5 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HT29, COLO205, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, COLO 205, MKN-74

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, HMEC

(see details)

3D Structures

At greater than 35% identity similarity to SLC7A1 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A1 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC7A1 has been screened with compounds ( bioactivities). (see details)