Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A1 (P30825) - Overview - Molecular Target Synopsis

Protein


SLC7A1, High affinity cationic amino acid transporter 1
UniProt P30825

Also Known as CTR1_HUMAN, SLC7A1, ATRC1, ERR, REC1L

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
629ENSG00000139514ENST00000380752ENSP00000370128P30825-1
128ENSG00000139514ENST00000450494ENSP00000390092

Sub-cellular localization


UniProt: SLC7A1 is active in the following subcellular-locations: cell membrane.
GO terms: SLC7A1 is active in the following subcellular-locations: integral component of plasma membrane, membrane, plasma membrane, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A1 has gain in 3 cell-lines, loss in 5 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, COLO205, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, COLO 205, MKN-74

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to SLC7A1 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A1 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6F34_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A1 has been screened with compounds ( bioactivities). (see details)