Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CRM1 (P30822) - Overview - Molecular Target Synopsis

Protein


CRM1, Exportin-1
UniProt P30822

Also Known as XPO1_YEAST, CRM1, KAP124, XPO1

Receptor for the leucine-rich nuclear export signal (NES). Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.

6A3B
MVM NES MUTANT NM13 IN COMPLEX WITH CRM1-RAN-RANBP1
RCSB/PDB
Inspect Structure
See all 3D Structures for CRM1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1084P30822-1

Sub-cellular localization


UniProt: CRM1 is active in the following subcellular-locations: cytoplasm, nucleus, perinuclear region.
GO terms: CRM1 is active in the following subcellular-locations: cytoplasm, integral component of membrane, kinetochore, nucleus, perinuclear region of cytoplasm, spindle pole body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CRM1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CRM1 there are:
46 structures (47 chains) solved
14 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CRM1 has been screened with compounds ( bioactivities). (see details)