Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTT1 (P30711) - Overview - Molecular Target Synopsis

Protein


GSTT1, Glutathione S-transferase theta-1
Enzyme Classification 2.5.1.18
UniProt P30711

Also Known as GSTT1_HUMAN, GSTT1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Homodimer.

2C3N
HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, APO FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTT1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
240ENSG00000184674ENST00000248935ENSP00000248935P30711-1
122ENSG00000184674ENST00000439996ENSP00000401632P30711-2

Sub-cellular localization


UniProt: GSTT1 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTT1 is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTT1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, COLO205, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


For GSTT1 there are:
3 structures (12 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTT1 has been screened with 5 compounds (5 bioactivities). (see details)