Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPCA (P30694) - Overview - Molecular Target Synopsis

Protein


PPCA, C4 phosphoenolpyruvate carboxylase
Enzyme Classification 4.1.1.31
UniProt P30694

Also Known as CAPPA_FLATR, PPCA

Forms oxaloacetate through the carboxylation of phosphoenolpyruvate (PEP). Catalyzes the first step of C4 photosynthesis. Homotetramer.

4BXC
RESOLVING THE ACTIVATION SITE OF POSITIVE REGULATORS IN PLANT PHOSPHOENOLPYRUVATE CARBOXYLASE
RCSB/PDB
Inspect Structure
See all 3D Structures for PPCA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
966P30694-1

Sub-cellular localization


UniProt: PPCA is active in the following subcellular-locations: cytoplasm.
GO terms: PPCA is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPCA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


PPCA was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For PPCA there are:
3 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis