Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PYK1 (P30615) - Overview - Molecular Target Synopsis

Protein


PYK1, Pyruvate kinase 1
Enzyme Classification 2.7.1.40
UniProt P30615

Also Known as KPYK1_TRYBB, PYK1

Homotetramer.

4KCT
PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH OXALOACETATE
RCSB/PDB
Inspect Structure
See all 3D Structures for PYK1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
499P30615-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project PYK1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PYK1 there are:
6 structures (12 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PYK1 has been screened with compounds ( bioactivities). (see details)