Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADSL (P30566) - Overview - Molecular Target Synopsis

Protein


ADSL, Adenylosuccinate lyase
Enzyme Classification 4.3.2.2
UniProt P30566

Also Known as PUR8_HUMAN, ADSL, AMPS

Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

4FFX
STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMAN ADENYLOSUCCINATE LYASE (ADSL) AND THE R303C ADSL DEFICIENCY ASSOCIATED MUTATION
RCSB/PDB
Inspect Structure
See all 3D Structures for ADSL

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ADSL is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADSL has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, HL_60, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JHH-7, SK-N-FI, KYSE-70

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


For ADSL there are:
4 structures (16 chains) solved
2 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ADSL is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2J91_A, 2J91_B, 2J91_C, 2J91_D, 2VD6_A, 2VD6_C),
FUM/FUMARIC ACID (2VD6_A, 2VD6_C).

(see details)
Molecular Target 3D Synopsis