CHRNA5 (P30532) - Overview - Molecular Target Synopsis
CHRNA5, Neuronal acetylcholine receptor subunit alpha-5
Also Known as ACHA5_HUMAN, CHRNA5, NACHRA5
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta). Interacts with LYPD6 (PubMed:27344019).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: CHRNA5 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: CHRNA5 is active in the following subcellular-locations: acetylcholine-gated channel complex, cell junction, dopaminergic synapse, integral component of plasma membrane, neuron projection, plasma membrane, postsynaptic membrane, synapse.