Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Gabra6 (P30191) - Overview - Molecular Target Synopsis

Protein


Gabra6, Gamma-aminobutyric acid receptor subunit alpha-6
UniProt P30191

Also Known as GBRA6_RAT, Gabra6, Gabra-6

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
453P30191-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project Gabra6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Gabra6 has been screened with 2912 compounds (5129 bioactivities), 1306 compounds have bioactivities that show binding affinity of <= 500nM (1839 bioactivities). (see details)