Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PEBP1 (P30086) - Overview - Molecular Target Synopsis

Protein


PEBP1, Phosphatidylethanolamine-binding protein 1
UniProt P30086

Also Known as PEBP1_HUMAN, PEBP1, PBP, PEBP

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation., HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

2L7W
SOLUTION STRUCTURE OF THE HUMAN RAF-1 KINASE INHIBITOR PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for PEBP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
187ENSG00000089220ENST00000261313ENSP00000261313P30086-1

Sub-cellular localization


UniProt: PEBP1 is active in the following subcellular-locations: cytoplasm.
GO terms: PEBP1 is active in the following subcellular-locations: apical part of cell, axon terminus, cell surface, cytosol, extracellular exosome, extracellular space, Golgi apparatus, mitochondrial outer membrane, mitochondrion, myelin sheath, neuronal cell body, nucleus, synaptic vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PEBP1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_257, RPMI_8226, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, Hep G2, SW 1463

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, A549

(see details)

3D Structures


For PEBP1 there are:
4 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis