Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRDX3 (P30048) - Overview - Molecular Target Synopsis

Protein


PRDX3, Thioredoxin-dependent peroxide reductase, mitochondrial
Enzyme Classification 1.11.1.15
UniProt P30048

Also Known as PRDX3_HUMAN, PRDX3, AOP1

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer (PubMed:17707404, PubMed:27238969). Interacts with NEK6 (PubMed:20873783). Interacts with LRRK2 (PubMed:21850687). Interacts with MAP3K13 (PubMed:12492477). Interacts with RPS6KC1 (via PX domain) (PubMed:15750338).

5UCX
STRUCTURE OF S78C HUMAN PEROXIREDOXIN 3 AS THREE STACKED RINGS
RCSB/PDB
Inspect Structure
See all 3D Structures for PRDX3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
256ENSG00000165672ENST00000298510ENSP00000298510P30048-1
238ENSG00000165672ENST00000356951ENSP00000349432P30048-2

Sub-cellular localization


UniProt: PRDX3 is active in the following subcellular-locations: cytoplasm, early endosome, mitochondrion.
GO terms: PRDX3 is active in the following subcellular-locations: cytoplasm, cytosol, early endosome, mitochondrial matrix, mitochondrion, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRDX3 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, HCT_116, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DV-90, A-375, SUIT-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, HeLa-S3

(see details)

3D Structures


For PRDX3 there are:
2 structures (18 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRDX3 has been screened with compounds ( bioactivities). (see details)