Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DDT (P30046) - Overview - Molecular Target Synopsis

Protein


DDT, D-dopachrome decarboxylase
Enzyme Classification 4.1.1.84
UniProt P30046

Also Known as DOPD_HUMAN, DDT

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Homotrimer.

6C5F
HUMAN D-DOPACHROME TAUTOMERASE (D-DT)/ MACROPHAGE MIGRATION INHIBITORY FACTOR 2 (MIF2) COMPLEXED WITH THE SELECTIVE INHIBITOR 4-CPPC
RCSB/PDB
Inspect Structure
See all 3D Structures for DDT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DDT is active in the following subcellular-locations: cytoplasm.
GO terms: DDT is active in the following subcellular-locations: cytoplasm, extracellular exosome, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DDT has gain in 5 cell-lines, loss in 3 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, SK_MEL_28, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EKVX, KYSE-520, COLO 699

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, HMEC

(see details)

3D Structures


For DDT there are:
4 structures (12 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DDT has been screened with compounds ( bioactivities). (see details)