Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRDX5 (P30044) - Overview - Molecular Target Synopsis

Protein


PRDX5, Peroxiredoxin-5, mitochondrial
Enzyme Classification 1.11.1.15
UniProt P30044

Also Known as PRDX5_HUMAN, PRDX5, ACR1

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Monomer.

4MMM
HUMAN PDRX5 COMPLEX WITH A LIGAND BP7
RCSB/PDB
Inspect Structure
See all 3D Structures for PRDX5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRDX5 is active in the following subcellular-locations: cytoplasm, mitochondrion, peroxisome matrix.
GO terms: PRDX5 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extracellular space, intracellular membrane-bounded organelle, mitochondrial matrix, mitochondrion, nucleus, perinuclear region of cytoplasm, peroxisomal matrix, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRDX5 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, EKVX, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HM7, SNU-398, COV362

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, HMEC

(see details)

3D Structures


For PRDX5 there are:
12 structures (37 chains) solved
10 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

PRDX5 is solved in complex with the approved drug(s):

BEZ/BENZOIC ACID (1H4O_A, 1H4O_B, 1H4O_C, 1H4O_D, 1H4O_E, 1H4O_F, 1H4O_G, 1H4O_H, 1HD2_A, 1OC3_A, 1OC3_B, 1URM_A, 2VL2_A, 2VL2_B).

(see details)
Molecular Target 3D Synopsis