Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRDX6 (P30041) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria14


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1PRX_B Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 61.2 30.7 Yes No
2 empty 1.88 65.1 17 No No
3 empty 2.43 66.9 10.8 No No
4 empty 2.24 65.9 17.1 No No
5 empty 1.57 54.3 16.2 No No
6 empty 2.17 60.7 13.5 No No
7 empty 2.44 64.2 15.7 No No
8 empty 2.25 68.4 9.9 No No
9 empty 1.94 57.8 13 No No
10 empty 2.08 72.2 7.9 No No
5B6N_D Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 61.1 29.3 Yes No
2 empty 2.1 63.9 21.5 No No
3 empty 1.63 70.7 19 No No
4 empty 1.74 60.8 19.9 No No
5 empty 2.04 67.2 21.3 No No
6 empty 1.68 61.6 17.9 No No
7 empty 2.09 55.1 13.9 No No
8 empty 2.15 84.3 11.5 Yes No
9 empty 2.31 68.3 11.8 No No
10 empty 2.15 63.5 10.4 No No
5B6M_D Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 59 29.7 Yes No
2 empty 1.83 68.7 20.7 No No
3 empty 1.81 70.3 26.9 No No
4 empty 1.81 64.9 18.5 No No
5 empty 1.8 64.9 19.2 No No
6 empty 2.39 91.7 0 Yes No
7 empty 1.72 55.6 12.4 No No
8 empty 1.39 72.2 9.2 No No
9 empty 1.83 57.2 10.7 No No
10 empty 2.08 66.1 9.8 No No
5B6M_B Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 59.9 26.2 Yes No
2 empty 2.14 66.5 27.6 No No
3 empty 2.47 63.5 16.8 No No
4 empty 2.54 61.2 21.5 No No
5 empty 2.03 59.1 23.2 No No
6 empty 1.79 59.8 17.6 No No
7 empty 2.01 62.3 14.1 No No
8 empty 2 73.2 10.4 No No
9 empty 2.19 66.5 16.7 No No
10 empty 1.63 72.4 11 No No
5B6N_F Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 59.2 24.6 Yes No
2 empty 2.56 65.7 23 No No
3 empty 2.3 62.7 20.8 No No
4 empty 2.28 59.7 22.4 No No
5 empty 1.73 57.8 16.6 No No
6 empty 1.83 70.1 9.6 No No
7 empty 2.31 68.2 10.1 No No
8 empty 1.8 74.7 10.4 No No
9 empty 1.62 67.8 12.3 No No
10 empty 1.76 67.7 10.9 No No
5B6N_A Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 61.6 29.7 Yes No
2 empty 2.58 63.9 20.7 No No
3 empty 2.06 59.2 19.8 No No
4 empty 2.19 60.2 23 No No
5 empty 1.72 59.7 17.6 No No
6 empty 2.04 68.3 21.2 No No
7 empty 2.88 66.3 19.4 No No
8 empty 2.33 69.2 13.4 No No
9 empty 1.84 74.9 9.4 No No
10 empty 1.85 68.4 9.9 No No
5B6M_F Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 59.1 25.9 Yes No
2 empty 2.52 62.4 22.7 No No
3 empty 2.37 61.4 18.7 No No
4 empty 2.66 65.6 17.7 No No
5 empty 1.9 70.2 16.3 No No
6 empty 1.62 60.5 16.5 No No
7 empty 1.9 73.4 10.4 No No
8 empty 1.85 68.9 10.5 No No
9 empty 2.34 67.1 9.9 No No
10 empty 1.68 61.6 12.3 No No
1PRX_A Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 62 31.3 Yes No
2 empty 2.6 67.3 18.1 No No
3 empty 2.57 65.7 23.9 No No
4 empty 1.97 60.5 15.6 No No
5 empty 1.61 64.2 10.3 No No
6 empty 2 53.6 15.1 No No
7 empty 2.15 60.9 14.3 No No
8 empty 2.04 72.9 7.2 No No
9 empty 1.71 70.4 10 No No
10 empty 2.74 62.5 16.4 No No
5B6M_E Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 61.6 29.7 Yes No
2 empty 1.88 67.2 21.1 No No
3 empty 2.36 64.1 22.7 No No
4 empty 2.1 63.8 24.9 No No
5 empty 1.53 60.7 16.1 No No
6 empty 2.76 72.1 12.5 No No
7 empty 1.81 68.2 10.8 No No
8 empty 1.85 68.1 13.1 No No
9 empty 1.12 86.3 12.3 Yes No
10 empty 2.36 68.5 7.7 No No
5B6N_C Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 60.9 28.9 Yes No
2 empty 2.11 64.9 27.1 No No
3 empty 2.05 57.9 22.7 No No
4 empty 2.69 64.6 13 No No
5 empty 1.86 61.8 18.1 No No
6 empty 2.12 63.2 18.9 No No
7 empty 2.17 63.8 19.2 No No
8 empty 1.7 73.6 9.9 No No
9 empty 1.91 65.2 8.2 No No
10 empty 2.06 63.8 14.4 No No
5B6M_C Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 61.4 30.2 Yes No
2 empty 2.34 60.9 20.6 No No
3 empty 1.81 55.8 21.8 No No
4 empty 2.5 64.6 13.7 No No
5 empty 2.12 64.9 15.8 No No
6 empty 1.86 69.1 10.1 No No
7 empty 2.14 68.6 10 No No
8 empty 2.45 66.5 14.8 No No
9 empty 2.3 65 13 No No
10 empty 1.62 71.3 10.3 No No
5B6N_E Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 64 27.1 Yes No
2 empty 2.28 58.6 24.1 No No
3 empty 2.53 60.4 21.7 No No
4 empty 2.81 69.2 17.4 No No
5 empty 1.92 60.9 16.7 No No
6 empty 1.85 71 20.2 No No
7 empty 2.13 73.2 9.5 No No
8 empty 2.35 65.1 12.6 No No
9 empty 1.97 64.7 17 No No
10 empty 2.31 67.9 9.2 No No
5B6M_A Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 58.8 27.9 Yes No
2 empty 2.2 63.2 26.3 No No
3 empty 2.41 55.3 22.8 No No
4 empty 1.89 58.7 18.1 No No
5 empty 2.67 67.2 15.8 No No
6 empty 1.77 59.4 11.8 No No
7 empty 1.97 70.5 11.1 No No
8 empty 2.36 62.8 12.5 No No
9 empty 1.97 68.9 13.9 No No
10 empty 1.67 77.3 8.5 No No
5B6N_B Peroxiredoxin-6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 60.1 31.7 Yes No
2 empty 2.55 62.6 23 No No
3 empty 2.39 62.1 15.3 No No
4 empty 2.05 68.5 18 No No
5 empty 1.85 58.9 23.3 No No
6 empty 2.22 65.5 18.2 No No
7 empty 1.69 60.2 17.3 No No
8 empty 1.78 64 14.8 No No
9 empty 2.35 62.2 12.2 No No
10 empty 1.9 70.3 10.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1PRX_A (33076) Peroxiredoxin-6 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 2Å Yes No
1PRX_A (4195313) Peroxiredoxin-6 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like (Homo Multimer) 2Å Yes No
1PRX_B (4195313) Peroxiredoxin-6 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like (Homo Multimer) 2Å Yes No
1PRX_B (33077) Peroxiredoxin-6 Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 2Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PRDX6 is involved in 14 interactions in the network.


Druggability
Overall Druggability Percentile: 91.04
Druggability for Cancer Therapeutics: 85.01
Druggability for Other Therapeutics: 55.72
Cancer-Associated
Cancer-associated percentile : 88.15
Network Articulation Point
Is PRDX6 critical for communication in the network?


Detailed Graph Legend:Help