Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRDX6 (P30041) - Overview - Molecular Target Synopsis

Protein


PRDX6, Peroxiredoxin-6
Enzyme Classification 1.11.1.15
UniProt P30041

Also Known as PRDX6_HUMAN, PRDX6, AOP2, KIAA0106

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Homodimer (PubMed:9587003, PubMed:27353378). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (By similarity). Interacts with APEX1 (PubMed:19188445). Interacts with STH (PubMed:16186110). May interact with FAM168B (PubMed:20716133). May interact with HTR2A.

5B6M
CRYSTAL STRUCTURE OF HUMAN PEROXIREDOXIN 6 IN REDUCED STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for PRDX6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
224ENSG00000117592ENST00000340385ENSP00000342026P30041-1

Sub-cellular localization


UniProt: PRDX6 is active in the following subcellular-locations: cytoplasm, lysosome.
GO terms: PRDX6 is active in the following subcellular-locations: azurophil granule lumen, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, membrane, nucleus, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRDX6 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, K_562, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G130, OVSAHO, PC-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, BJ, NHLF

(see details)

3D Structures


For PRDX6 there are:
3 structures (14 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis