Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CRABP1 (P29762) - Overview - Molecular Target Synopsis

Protein


CRABP1, Cellular retinoic acid-binding protein 1
UniProt P29762

Also Known as RABP1_HUMAN, CRABP1, RBP5

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
137ENSG00000166426ENST00000299529ENSP00000299529P29762-1
116ENSG00000166426ENST00000406419ENSP00000385978

Sub-cellular localization


UniProt: CRABP1 is active in the following subcellular-locations: cytoplasm.
GO terms: CRABP1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CRABP1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, SW_620, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-AS, PA-1, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: H1-hESC, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 90% identity similarity to CRABP1 there are:
3 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CRABP1 has been screened with 14 compounds (14 bioactivities). (see details)