Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Lalba (P29752) - Overview - Molecular Target Synopsis

Protein


Lalba, Alpha-lactalbumin
UniProt P29752

Also Known as LALBA_MOUSE, Lalba

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. Lactose synthase (LS) is heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

2FYD
CATALYTIC DOMAIN OF BOVINE BETA 1, 4-GALACTOSYLTRANSFERASE IN COMPLEX WITH ALPHA-LACTALBUMIN, GLUCOSE, MN, AND UDP-N- ACETYLGALACTOSAMINE
RCSB/PDB
Inspect Structure
See all 3D Structures for Lalba

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
143P29752-1

Sub-cellular localization


UniProt: Lalba is active in the following subcellular-locations: secreted.
GO terms: Lalba is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Lalba has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Lalba there are:
12 structures (24 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Lalba has been screened with compounds ( bioactivities). (see details)