Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

XOG1 (P29717) - Overview - Molecular Target Synopsis

Protein


XOG1, Glucan 1,3-beta-glucosidase
Enzyme Classification 2.4.1.-
UniProt P29717

Also Known as EXG1_CANAL, XOG1, EXG, EXG1, XOG

Major glucan 1,3-beta-glucosidase required for cell wall integrity. Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Can also function biosynthetically as a transglycosylase. Functions to deliver glucan from the cell to the extracellular matrix. Does not appear to impact cell wall glucan content of biofilm cells, nor is it necessary for filamentation or biofilm formation. Involved in cell-substrate and cell-cell adhesion. Adhesion to host-cell surfaces is the first critical step during mucosal infection. XOG1 is target of human antimicrobial peptide LL-37 for inhibition of cell adhesion. Monomer. Interacts with the human antimicrobial peptide LL-37.

4M80
THE STRUCTURE OF E292S GLYCOSYNTHASE VARIANT OF EXO-1,3-BETA-GLUCANASE FROM CANDIDA ALBICANS AT 1.85A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for XOG1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
438P29717-1

Sub-cellular localization


UniProt: XOG1 is active in the following subcellular-locations: cell wall, secreted.
GO terms: XOG1 is active in the following subcellular-locations: cell surface, cell wall, extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project XOG1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For XOG1 there are:
12 structures (12 chains) solved
6 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

XOG1 is solved in complex with the approved drug(s):

G2F/FLUDEOXYGLUCOSE (2PB1_A),
BGC/DEXTROSE (2PC8_A, 3N9K_A, 4M82_A).

(see details)
Molecular Target 3D Synopsis