Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TYK2 (P29597) - Overview - Molecular Target Synopsis

Protein


TYK2, Non-receptor tyrosine-protein kinase TYK2
Enzyme Classification 2.7.10.2
UniProt P29597

Also Known as TYK2_HUMAN, TYK2

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Interacts with JAKMIP1.

6DBK
TYK2 WITH COMPOUND 8
RCSB/PDB
Inspect Structure
See all 3D Structures for TYK2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: TYK2 is active in the following subcellular-locations: cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TYK2 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, SR, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L26, OCI-M2, MDA-MB-468

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, IMR-90

(see details)

RNA Interference


TYK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAMA1, SUM149. (see details)

3D Structures


For TYK2 there are:
24 structures (28 chains) solved
22 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TYK2 is solved in complex with the approved drug(s):

MI1/TOFACITINIB (3LXN_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TYK2 has been screened with 1272 compounds (1954 bioactivities), 380 compounds have bioactivities that show binding affinity of <= 500nM (473 bioactivities). (see details)