Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TYK2 (P29597) - Overview - Molecular Target Synopsis


TYK2, Non-receptor tyrosine-protein kinase TYK2
Enzyme Classification
UniProt P29597

Also Known as TYK2_HUMAN, TYK2

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Interacts with JAKMIP1.

6DBK deposition date (2018-05-03)
Inspect Structure
See all 3D Structures for TYK2

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

Gene Copy Number Variation

In COSMIC - Cell Lines Project TYK2 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: PC_3, SR, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L26, OCI-M2, MDA-MB-468

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, IMR-90

(see details)

RNA Interference

TYK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAMA1, SUM149. (see details)

3D Structures

For TYK2 there are:
24 structures (28 chains) solved
22 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TYK2 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TYK2 has been screened with 1272 compounds (1954 bioactivities), 380 compounds have bioactivities that show binding affinity of <= 500nM (473 bioactivities). (see details)