Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Nos1 (P29476) - Overview - Molecular Target Synopsis

Protein


Nos1, Nitric oxide synthase, brain
Enzyme Classification 1.14.13.39
UniProt P29476

Also Known as NOS1_RAT, Nos1, Bnos

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON (By similarity). Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location. Interacts with HTR4 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with VAC14. Interacts (via N-terminal domain) with DLG4 (via N-terminal tandem pair of PDZ domains).

6NGV
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(3-(3-(DIMETHYLAMINO)PROPYL)-2,5,6-TRIFLUOROPHENETHYL)-4- METHYLPYRIDIN-2-AMINE
RCSB/PDB
Inspect Structure
See all 3D Structures for Nos1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1463P29476-3
1429P29476-1
1324P29476-2

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project Nos1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Nos1 there are:
281 structures (554 chains) solved
276 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Nos1 has been screened with 1719 compounds (2847 bioactivities), 272 compounds have bioactivities that show binding affinity of <= 500nM (326 bioactivities). (see details)