Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PAP1 (P29468) - Overview - Molecular Target Synopsis

Protein


PAP1, Poly(A) polymerase
Enzyme Classification 2.7.7.19
UniProt P29468

Also Known as PAP_YEAST, PAP1

Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Interacts with FIR1 and RRP6.

3C66
YEAST POLY(A) POLYMERASE IN COMPLEX WITH FIP1 RESIDUES 80-105
RCSB/PDB
Inspect Structure
See all 3D Structures for PAP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
568P29468-1

Sub-cellular localization


UniProt: PAP1 is active in the following subcellular-locations: nucleus.
GO terms: PAP1 is active in the following subcellular-locations: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PAP1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PAP1 there are:
5 structures (8 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis