Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IL12B (P29460) - Overview - Molecular Target Synopsis

Protein


IL12B, Interleukin-12 subunit beta
UniProt P29460

Also Known as IL12B_HUMAN, IL12B, NKSF2

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC., Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.

5NJD
STRUCTURE OF INTERLEUKIN 23 IN COMPLEX WITH BRIAKINUMAB FAB
RCSB/PDB
Inspect Structure
See all 3D Structures for IL12B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
328ENSG00000113302ENST00000231228ENSP00000231228P29460-1

Drugs


IL12B is targeted by Approved Drug Ustekinumab. (see details)
Ustekinumab

Sub-cellular localization


UniProt: IL12B is active in the following subcellular-locations: secreted.
GO terms: IL12B is active in the following subcellular-locations: cytosol, endoplasmic reticulum lumen, external side of plasma membrane, extracellular region, extracellular space, interleukin-12 complex, interleukin-23 complex, late endosome lumen, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IL12B has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, CAKI_1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-3, OCI-LY-10, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For IL12B there are:
13 structures (21 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


IL12B has been screened with 1 compounds (1 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)